ArticleScience translational medicine2022
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Mechanistic Insights into CFTR Potentiation by the Antimicrobial Peptide Esc(1-21): Direct Interaction with the NBD1-NBD2 Interface.ACS omega · 2026Article
- Regulation of CFTR stability at the plasma membrane-Mechanisms and therapeutic opportunities in cystic fibrosis.FEBS letters · 2026Review
- A renaissance in targeting the PI3K/AKT/mTOR pathway.Nature reviews. Drug discovery · 2026Review
- Formononetin as a potential therapeutic agent for asthma: evidence from in vivo and in vitro models of attenuated inflammation via cAMP/PKA pathway inhibition.In vitro cellular & developmental biology. Animal · 2026Article
- Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation.Scientific reports · 2026Article
- Targeting PI3Kγ anchoring enhances CFTR membrane localization and modulator efficacy via PKD1.JCI insight · 2026Article
- Review
- A softness zwitterionic micelles efficiently deliver inhaled nintedanib by enhancing airway mucus penetration.Science advances · 2026Article
- Beyond the mutations: spatiotemporal regulation of CFTR by cAMP and calcium signaling in epithelial physiology and cystic fibrosis.Cellular & molecular biology letters · 2025Review
- Impaired cAMP-PKA-CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia.Nature metabolism · 2025Article
- Development and validation of a risk model for effective immune and stromal related signature predicting prognosis of patients with ovarian cancer.Scientific reports · 2025Article
- Review
- Esc peptides and derivatives potentiate the activity of CFTR with gating defects and display antipseudomonal activity in cystic fibrosis-like lung disease.Cellular and molecular life sciences : CMLS · 2025Article
- SUMOylation Inhibition Enhances Protein Transcription under CMV Promoter: A Lesson from a Study with the F508del-CFTR Mutant.International journal of molecular sciences · 2024Article
- Cell type-specific regulation of CFTR trafficking-on the verge of progress.Frontiers in cell and developmental biology · 2024Review
- It Takes Two to Tango! Protein-Protein Interactions behind cAMP-Mediated CFTR Regulation.International journal of molecular sciences · 2023Review
- Molecular mechanisms of cystic fibrosis - how mutations lead to misfunction and guide therapy.Bioscience reports · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 19 institutions in 7 countries.
Alessandra GhigoDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0002-1193-5296
Alessandra MurabitoDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0003-3039-4285
Valentina SalaDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0002-2283-2807
Anna Rita PisanoChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, 43122 Parma, Italy.
Serena BertoliniChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, 43122 Parma, Italy.
Ambra GianottiUOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Emanuela CaciUOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Alessio MontresorDivision of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.ORCID 0000-0001-6509-4958
Aiswarya PremchandarDepartment of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada.ORCID 0000-0002-5664-496X
Flora PirozziDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0003-3575-1763
Kai RenDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
Angela Della SalaDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
Marco MergiottiDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
Wito RichterDepartment of Biochemistry and Molecular Biology, University of South Alabama College of Medicine Mobile, AL 36688, USA.ORCID 0000-0001-5588-9060
Eyleen de PoelDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, Netherlands.
Michaela MattheyDepartment of Systems Physiology, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.
Sara CaldrerDivision of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.ORCID 0000-0002-2379-1082
Rosa A CardoneDepartment of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari , 70126 Bari, Italy.
Federica CivilettiDepartment of Anesthesia and Critical Care Medicine, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
Andrea CostamagnaDepartment of Anesthesia and Critical Care Medicine, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, 10126 Torino, Italy.ORCID 0000-0002-0231-1545
Nancy L QuinneyMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-3437-9621
Cosmin ButnarasuDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0001-8620-3391
Sonja VisentinDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0001-7262-6166
Maria Rosaria RuggieroDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0003-2374-6692
Simona BaroniDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0002-8683-3083
Simonetta Geninatti CrichDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0003-2998-5424
Damien RamelInstitute of Metabolic and Cardiovascular Diseases, Paul Sabatier University , 31432 Toulouse, France.ORCID 0000-0002-9089-1497
Muriel LaffargueInstitute of Metabolic and Cardiovascular Diseases, Paul Sabatier University , 31432 Toulouse, France.
Carlo G TocchettiDepartment of Translational Medical Sciences, Federico II University, 80131 Naples, Italy.ORCID 0000-0001-5983-688X
Renzo LeviDepartment of Life Sciences and Systems Biology, University of Torino, 10123 Torino, Italy.ORCID 0000-0003-0530-8496
Marco ContiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-4755-9146
Xiao-Yun LuSchool of life Science and Technology, Xi'an Jiaotong University, 710049 Xi'an Shaanxi, P.R. China.ORCID 0000-0003-3284-4729
Paola MelottiCystic Fibrosis Center, Azienda Ospedaliera Universitaria Integrata di Verona, 37126 Verona, Italy.
Claudio SorioDivision of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.
Virginia De RoseDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.
Fabrizio FacchinettiChiesi Farmaceutici S.p.A., Corporate Pre-Clinical R&D, 43122 Parma, Italy.
Vito FanelliDepartment of Anesthesia and Critical Care Medicine, University of Torino, Azienda Ospedaliera Città della Salute e della Scienza di Torino, 10126 Torino, Italy.
Daniela WenzelDepartment of Systems Physiology, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.ORCID 0000-0003-1100-6363
Bernd K FleischmannInstitute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-9202-8363
Marcus A MallDepartment of Pediatric Respiratory Medicine, Immunology, and Critical Care Medicine, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.ORCID 0000-0002-4057-2199
Jeffrey BeekmanDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3584 EA Utrecht, Netherlands.ORCID 0000-0003-4886-3756
Carlo LaudannaDivision of General Pathology, Department of Medicine, University of Verona School of Medicine , 37134 Verona, Italy.ORCID 0000-0003-4050-1056
Martina GentzschMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Gergely L LukacsDepartment of Physiology, McGill University, Montréal, Quebec H3G 1Y6, Canada.ORCID 0000-0003-0900-0675
Nicoletta PedemonteUOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0002-5161-1720
Emilio HirschDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino , 10126 Torino, Italy.ORCID 0000-0002-9073-6024
University of Turin · ITUniversity of Verona · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITChiesi Foundation · ITIstituto Giannina Gaslini · ITTorino e-district · ITFederico II University Hospital · ITMcGill University · CAUniversité Toulouse III - Paul Sabatier · FRUniversity of Bonn · DEUniversity of North Carolina at Chapel Hill · USWilhelmina Children's Hospital · NLAzienda Ospedaliera Universitaria Integrata Verona · ITGerman Center for Lung Research · DERuhr University Bochum · DEUniversity of Bari Aldo Moro · ITUniversity of California, San Francisco · USUniversity of South Alabama · USXi'an Jiaotong University · CN
Funding
Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5MCIHR PJT 153095NIDDK NIH HHS P30 DK065988
Abstract
Cyclic adenosine 3',5'-monophosphate (cAMP)-elevating agents, such as β
Indexed as
Cystic Fibrosis Transmembrane Conductance RegulatorPhosphatidylinositol 3-KinaseAnimalsClass Ib Phosphatidylinositol 3-KinaseHumansInflammationMicePeptidesPhosphatidylinositol 3-KinasesCFTR protein, humanClass Ib Phosphatidylinositol 3-KinaseCystic Fibrosis Transmembrane Conductance RegulatorPeptidesPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPIK3CG protein, humanPik3cg protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.