ArticleThe Laryngoscope2022
Depression Symptoms and Olfactory-related Quality of Life.
Article in The Laryngoscope, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of sensory changes in post-COVID syndrome: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Efficacy of Gabapentin For Post-COVID-19 Olfactory Dysfunction: The GRACE Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2023Trial
- Emotional Burden of Olfactory Dysfunction: A Psychological Cluster Analysis from a Tertiary Smell and Taste Clinic.International forum of allergy & rhinology · 2026Article
- Olfactory assessment in treatment and survivor groups of pediatric solid malignancies.Discover oncology · 2026Article
- Human olfactory sensitivity varies across geographical locations.Scientific reports · 2026Article
- Characterizing Neuro-PASC outcome with the mobile Neuro-COVID recovery care companion application.BMC neurology · 2026Article
- Swedish translation and cultural adaptation of the General Well-Being Schedule for patients with olfactory and hearing dysfunction.Frontiers in psychology · 2026Article
- Supervised Machine Learning Analysis of Food-Related Quality of Life Impact in Olfactory Dysfunction.The Laryngoscope · 2026Article
- Comparison between olfactory bulb and olfactory tract implantations through an endoscopic supraorbital keyhole approach: a cadaveric study.Acta neurochirurgica · 2025Article
- Scenting the Hedonic Connection: Exploring the Impact of Subjective Olfactory Dysfunction on Depressive Symptoms.PsyCh journal · 2025Article
- Subjective distress mediates the association between olfactory dysfunction duration and depression in post COVID 19 patients.Scientific reports · 2025Article
- Sensing Sociality: Disruptions of Social Life When Living With Chemosensory Dysfunctions After COVID-19.Qualitative health research · 2025Article
- Factors Associated With Persisting Olfactory Dysfunction After COVID-19.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- Olfactory loss in people with cystic fibrosis: Community perceptions and impact.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2024Article
- The olfactory diary: Tracking awareness and consciousness of the sense of smell throughout the day.Laryngoscope investigative otolaryngology · 2024Article
- The Correlation between the Results of the Sniffin' Sticks Test, Demographic Data, and Questionnaire of Olfactory Disorders in a Hungarian Population after a SARS-CoV-2 Infection.Journal of clinical medicine · 2023Article
- Abnormal functional connectivity of the core olfactory network in patients with chronic rhinosinusitis accompanied by olfactory dysfunction.Frontiers in neurology · 2023Article
- Regional homogeneity alterations of resting-state functional magnetic resonance imaging of chronic rhinosinusitis with olfactory dysfunction.Frontiers in neuroscience · 2023Article
- Impairment of quality of life due to COVID-19-induced long-term olfactory dysfunction.Frontiers in psychology · 2023Article
- Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression.Frontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPatients with olfactory dysfunction (OD) frequently report symptoms of depression. The objective of this study was to determine how clinical characteristics and olfactory-related quality of life (QoL) measures associate with the likelihood for major depressive disorders (MDDs).
methodsA total of 192 OD patients were included. Olfactory function was measured using all three subtests of the Sniffn' Sticks test. Olfactory-related quality of life (QoL) was evaluated using the Questionnaires of Olfactory Dysfunction (QOD)-negative (NS) and -positive statement (PS). The likelihood for MDD was assessed using the Patients Health Questionnaire-2 (PHQ-2). Demographics and disease-specific variables (etiology and duration of OD) were collected. Univariate and multivariable analyses were used to associate disease-specific variables and the QOD with the outcome of the PHQ-2. Additionally, the predictive ability of the QOD-NS to predict depressive symptoms was calculated.
resultsIn univariate analysis, COVID-19 related smell loss, the QOD-NS, and the QOD-PS were significantly associated with the PHQ-2. In multivariable analyses adjusting for QoL measures, the QOD-NS (ß = 0.532, p < 0.001) and sinonasal OD (compared with postinfectious OD) were significantly associated with the PHQ-2 (ß = 0.146, p = 0.047). When omitting QoL measures from multivariable analyses, only COVID-19 related OD (compared with postinfectious OD) was significantly associated with the PHQ-2 (ß = 0.287, p = 0.009). A QOD-NS score > 20.5 had 70.13% sensitivity and 76.32% specificity for detecting symptoms of depression.
conclusionOur results suggest that COVID-19 related OD might be associated with a higher likelihood for MDD. Furthermore, we showed that the QOD-NS score might be helpful to predict symptoms of depression in OD patients. LEVEL OF EVIDENCE: 4 Laryngoscope, 132:1829-1834, 2022.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.