Evidence map›Paper›PMID 35353274›Full record

ArticleMetabolic brain disease2022

An exploratory pilot study on the involvement of APOE, HFE, C9ORF72 variants and comorbidities in neurocognitive and physical performance in a group of HIV-infected people.

Isabella Zanella, Eliana Zacchi, Chiara Fornari, Benedetta Fumarola, Melania Degli Antoni, Daniela Zizioli, Eugenia Quiros-Roldan, Inflammation in H. I. V. Study Group

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isabella ZanellaDepartment of Molecular and Translational Medicine, University of Brescia, 25123, Brescia, Italy. isabella.zanella@unibs.it.ORCID http://orcid.org/0000-0003-3902-3376
Eliana ZacchiDepartment of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.
Chiara FornariDepartment of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.
Benedetta FumarolaDepartment of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.
Melania Degli AntoniDepartment of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.
Daniela ZizioliDepartment of Molecular and Translational Medicine, University of Brescia, 25123, Brescia, Italy.ORCID http://orcid.org/0000-0003-0451-8029
Eugenia Quiros-RoldanDepartment of Clinical and Experimental Sciences, University of Brescia, 25123, Brescia, Italy.ORCID http://orcid.org/0000-0003-1452-9100
Inflammation in H. I. V. Study Group
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline of aging is modulated by chronic inflammation and comorbidities. In people with HIV-infection (PWH) it may also be affected by HIV-induced inflammation, lifestyle and long-term effects of antiretroviral therapies (ART). The role of genetics in the susceptibility to HIV-associated neurocognitive disorders (HAND) is not fully understood. Here we explored the possible relations among variants in 3 genes involved in inflammation and neurodegenerative disorders (APOE: ε2/ε3/ε4; HFE: H63D; C9ORF72: hexanucleotide expansions ≥ 9 repeats), cognitive/functional impairment (MiniMental State Examination MMSE, Clock Drawing Test CDT, Short Physical Performance Battery SPPB), comorbidities and HIV-related variables in a cohort of > 50 years old PWH (n = 60) with at least 10 years efficient ART. Patients with diabetes or hypertension showed significantly lower MMSE (p = .031) or SPPB (p = .010) scores, respectively, while no relations between HIV-related variables and cognitive/functional scores were observed. Patients with at least one APOEε3 allele had higher CDT scores (p = .019), APOEε2/ε4 patients showing the lowest scores in all tests. Patients with HFE-H63D variant showed more frequently hypertriglyceridemia (p = .023) and those harboring C9ORF72 expansions > 9 repeats had higher CD4

Indexed as

HIV InfectionsPhysical Functional PerformanceApolipoproteins EC9orf72 ProteinGenotypeHemochromatosis ProteinHumansInflammationMiddle AgedNeuropsychological TestsPilot ProjectsApoE protein, humanApolipoproteins EC9orf72 ProteinC9orf72 protein, humanHemochromatosis ProteinHFE protein, humanAPOEC9ORF72ComorbiditiesHFEHIVNeurocognitive/physical performance

Identifiers

PMID35353274
PMCPMC8964929
OpenAlexW4221088762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.