Evidence map›Paper›PMID 35353203›Full record

ArticlePsychopharmacology2022

The interaction between Environmental Enrichment and fluoxetine in inhibiting sucrose-seeking renewal in mice depend on social living condition.

N Pintori, A Piva, V Guardiani, C M Marzo, I Decimo, C Chiamulera

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

N PintoriSection of Pharmacology, Department of Diagnostic and Public Health, Policlinico 'GB Rossi', P.le Scuro 10, University of Verona, 37134, Verona, Italy. nicholas.pintori@univr.it.
A PivaSection of Pharmacology, Department of Diagnostic and Public Health, Policlinico 'GB Rossi', P.le Scuro 10, University of Verona, 37134, Verona, Italy.
V GuardianiSection of Pharmacology, Department of Diagnostic and Public Health, Policlinico 'GB Rossi', P.le Scuro 10, University of Verona, 37134, Verona, Italy.
C M MarzoDepartment of Biotechnology, University of Verona, Verona, Italy.
I DecimoSection of Pharmacology, Department of Diagnostic and Public Health, Policlinico 'GB Rossi', P.le Scuro 10, University of Verona, 37134, Verona, Italy.
C ChiamuleraSection of Pharmacology, Department of Diagnostic and Public Health, Policlinico 'GB Rossi', P.le Scuro 10, University of Verona, 37134, Verona, Italy.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleSeveral single or combined therapeutic approaches have been developed to treat addiction, however with partial efficacy in preventing relapse. Recently, the living environment has been suggested as a critical intervening factor determining the treatment outcomes. Despite accumulating evidence confirming a role of living conditions in the vulnerability to addictive behaviours, their impact on single or integrative therapeutic strategies preventing relapse is yet to be identified.

objectivesHere, we explore the possible interaction between brief Environmental Enrichment (EE) exposure and acute fluoxetine administration in inhibiting sucrose-seeking behaviours, and whether this effect could be affected by living environment.

methodsSocial and isolated adult male C57BL/6 mice were trained to sucrose self-administration associated to a specific conditioning context (CxA), followed by a 7-day extinction in a different context (CxB). Afterwards, mice were exposed for 22 h to EE and then injected with fluoxetine (10 mg/kg, i.p.) 1 h before a CxA-induced sucrose-seeking test.

resultsBrief EE exposure and acute fluoxetine administration alone inhibited context-induced sucrose-seeking in both housing conditions; however, they exhibited additive properties only in social condition.

conclusionsOur data show that social environment may influence the EE/fluoxetine interaction in inhibiting relapse to sucrose. These findings suggest that setting up proper living conditions to boost the efficacy of therapeutic approaches may represent a fundamental strategy to treat addiction disorders.

Indexed as

FluoxetineSucroseAnimalsEnvironmentMaleMiceMice, Inbred C57BLRecurrenceSelf AdministrationSocial ConditionsFluoxetineSucroseConditioningEnvironmental EnrichmentFluoxetineLiving environmentMiceRenewalSeeking behavioursSucrose

Identifiers

PMID35353203
PMCPMC9205808
OpenAlexW4220695892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.