Observational studyAge and ageing2022
A multi-centre cohort study on healthcare use due to medication-related harm: the role of frailty and polypharmacy.
Observational study in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Inappropriate prescribing and association with readmission or mortality in hospitalised older adults with frailty: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Prevalence and assessment of frailty in interstitial lung disease - a systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Use of medications with pharmacogenomic guidelines and adverse outcomes in hospitalised older patients: a retrospective cross-sectional study.The pharmacogenomics journal · 2026Article
- Adverse Drug Reaction-Related Hospital Admissions and Adverse Drug Events and Their Association with Short- and Long-Term Health Outcomes in Older Adults.Geriatrics (Basel, Switzerland) · 2026Article
- Validity of the Medication Safety Self-Assessment for Long-Term Care tool in Australian long-term care: a RAND appropriateness method study.British journal of clinical pharmacology · 2025Article
- Adverse drug reactions and events in an Ageing PopulaTion risk Prediction (ADAPTiP) tool: the development and validation of a model for predicting adverse drug reactions and events in older patients.European geriatric medicine · 2025Article
- Relationship between medication safety-related processes and medication use in residential aged care facilities.Australasian journal on ageing · 2024Article
- New horizons in clinical practice guidelines for use with older people.Age and ageing · 2024Article
- 'I think we could probably do more': an interview study to explore community pharmacists' experiences and perspectives of frailty and optimising medicines use in frail older adults.Age and ageing · 2024Article
- Nomogram model for screening the risk of frailty in older adult atrial fibrillation patients: a cross-sectional study.Frontiers in public health · 2024Article
- Co-designing an intervention to improve the process of deprescribing for older people living with frailty in the United Kingdom.Health expectations : an international journal of public participation in health care and health policy · 2023Article
- Recent Updates on Risk and Management Plans Associated with Polypharmacy in Older Population.Geriatrics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo determine the association between frailty and medication-related harm requiring healthcare utilisation.
designProspective observational cohort study.
settingSix primary and five secondary care sites across South East England, September 2013-November 2015.
participantsOne thousand and two hundred and eighty participants, ≥65 years old, who were due for discharge from general medicine and older persons' wards following an acute episode of care. Exclusion criteria were limited life expectancy, transfer to another hospital and consent not gained.
main outcome measuresMedication-related harm requiring healthcare utilisation (including primary, secondary or tertiary care consultations related to MRH), including adverse drug reactions, non-adherence and medication error determined via the review of data from three sources: patient/carer reports gathered through a structured telephone interview; primary care medical record review; and prospective consultant-led review of readmission to recruiting hospital. Frailty was measured using a Frailty Index, developed using a standardised approach. Marginal estimates were obtained from logistic regression models to examine how probabilities of healthcare service use due to medication-related harm were associated with increasing number of medicines and frailty.
resultsHealthcare utilisation due to medication-related harm was significantly associated with frailty (OR = 10.06, 95% CI 2.06-49.26, P = 0.004), independent of age, gender, and number of medicines. With increasing frailty, the need for healthcare use as a result of MRH increases from a probability of around 0.2-0.4. This is also the case for the number of medicines.
conclusionsFrailty is associated with MRH, independent of polypharmacy. Reducing the burden of frailty through an integrated health and social care approach, alongside strategies to reduce inappropriate polypharmacy, may reduce MRH related healthcare utilisation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.