Evidence map›Paper›PMID 35353000›Full record

ArticleJournal of virology2022

The

Han Wan, Rebecca L Adams, Brett D Lindenbach, Anna Marie Pyle

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. A passive protein environment offsets RNA folding energetics in cells.bioRxiv : the preprint server for biology · 2026
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  6. "Fertile" Mutations in SARS-CoV-2 RNA More Frequently Occurred in Hairpin Loops That Determine Virus Evolution.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025
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  15. The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Han WanDepartment of Molecular, Cellular, and Developmental Biology, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Rebecca L AdamsDepartment of Molecular, Cellular, and Developmental Biology, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.
Brett D LindenbachDepartment of Microbial Pathogenesis, Yale Universitygrid.47100.32 School of Medicine, New Haven, Connecticut, USA.
Anna Marie PyleDepartment of Molecular, Cellular, and Developmental Biology, Yale Universitygrid.47100.32, New Haven, Connecticut, USA.ORCID 0000-0001-9045-8872
Howard Hughes Medical Institute · USYale University · US

Funding

Hepatitis C virus genome structure: dynamic roles in replication and infectivityR01AI131518 · NIAID · YALE UNIVERSITY · PI LINDENBACH, BRETT D., PYLE, ANNA MARIE · 2017 to 2020
$2.3M
RNA-Protein Interactions During Hepatitis C Virus InfectionF32AI126660 · NIAID · YALE UNIVERSITY · PI ADAMS, REBECCA LYNN · 2016 to 2018
$174k
NIAID NIH HHS F32 AI126660NIAID NIH HHS R01 AI131518
6 · The paper itself

Abstract

Hepatitis C virus (HCV) is a positive-strand RNA virus that remains one of the main contributors to chronic liver disease worldwide. Studies over the last 30 years have demonstrated that HCV contains a highly structured RNA genome and many of these structures play essential roles in the HCV life cycle. Despite the importance of riboregulation in this virus, most of the HCV RNA genome remains functionally unstudied. Here, we report a complete secondary structure map of the HCV RNA genome

Indexed as

Genome, ViralHepacivirusRNA, ViralHepatitis CHumansRNA, UntranslatedRNA, UntranslatedRNA, ViralHCVpseudoknotRNA foldingSHAPEviral replication

Identifiers

PMID35353000
PMCPMC9044954
OpenAlexW4220844853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.