Evidence map›Paper›PMID 35352867›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2022

In vitro and in vivo methods to study bacterial colonization of hydrogel dermal fillers.

Yi Wang, Rachel M Borthwell, Kellyn Hori, Samuel Clarkson, Gideon Blumstein, Howard Park, Christopher M Hart, Christopher D Hamad, Kevin P Francis, Nicholas M Bernthal and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi WangDivision of Biology, Chemistry and Materials Science, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Office of Medical Products and Tobacco, United States Food and Drug Administration, Silver Spring, Maryland, USA.
Rachel M BorthwellDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Kellyn HoriDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Samuel ClarksonDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Gideon BlumsteinDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Howard ParkDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Christopher M HartDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Christopher D HamadDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Kevin P FrancisDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
Nicholas M BernthalDepartment of Orthopaedic Surgery, Orthopaedic Hospital Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA.
K Scott PhillipsDivision of Biology, Chemistry and Materials Science, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Office of Medical Products and Tobacco, United States Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0002-6552-0694

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
NIAMS NIH HHS T32 AR059033
6 · The paper itself

Abstract

Preclinical in vitro and in vivo methods to study bacterial interactions with dermal fillers and infection pathogenesis are lacking. In this work, first in vitro methods to assess protein biofouling and effective pore size of commercial dermal fillers, including degradable hyaluronic acid (HA)-based fillers and other semi-degradable or permanent fillers (non-HA), were developed. The results were then related to Staphylococcus aureus (S. aureus) adhesion rates in vitro. HA fillers had less protein sorption than non-HA fillers and overall had smaller effective pore sizes. The properties correlated with levels of bacterial adhesion, where the control glass surface had the most rapid increase in bacterial cell adhesion, with a slope of 0.29 cm

Indexed as

Dermal FillersAnimalsHyaluronic AcidHydrogelsMiceStaphylococcus aureusDermal FillersHyaluronic AcidHydrogelsanimal modelbacterial colonizationbiofoulingdermal fillerin vitroin vivostaphylococci

Identifiers

PMID35352867
PMCPMC10371418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.