Evidence map›Paper›PMID 35352795›Full record

SynthesisAge and ageing2022

Prevalence and implications of frailty in acute stroke: systematic review & meta-analysis.

Jennifer K Burton, Jennifer Stewart, Mairi Blair, Sinead Oxley, Amy Wass, Martin Taylor-Rowan, Terence J Quinn

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 10 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 10 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Jennifer K BurtonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Jennifer StewartGlasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UK.
Mairi BlairQueen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UK.
Sinead OxleyGlasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UK.
Amy WassForth Valley Royal Hospital, NHS Forth Valley, Larbert, UK.
Martin Taylor-RowanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Terence J QuinnInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
University of Glasgow · GBForth Valley Royal Hospital · GBGlasgow Royal Infirmary · GBNHS Greater Glasgow and Clyde · GBQueen Elizabeth University Hospital · GB

Funding

Chief Scientist Office PCL/21/01
6 · The paper itself

Abstract

backgroundfrailty is common in older adults and associated with poor outcomes following illness. Although stroke is predominantly a disease of older people, our knowledge of frailty in stroke is limited. We aimed to collate the literature on acute stroke and frailty to estimate the prevalence of pre-stroke frailty and its associations with outcomes.

methodspaired researchers searched multidisciplinary electronic databases for papers describing frailty and acute stroke. We assessed risk of bias using Newcastle-Ottawa tools appropriate to study design. We created summary estimates of pre-stroke frailty using random effects models. We collated whether studies reported significant positive associations between frailty and clinical outcomes in adjusted models.

resultswe included 14 studies (n = 27,210 participants). Seven studies (n = 8,840) used a frailty index approach, four studies (n = 14,924) used Hospital Frailty Risk Scores. Pooled prevalence of pre-stroke frailty was 24.6% (95% confidence interval, CI: 16.2-33.1%; low quality evidence, downgraded due to heterogeneity, bias). Combining frailty and pre-frailty (nine studies, n = 23,827), prevalence of any frailty syndrome was 66.8% (95%CI: 49.9-83.7%). Seven studies were at risk of bias, from participant selection or method of frailty assessment. Pre-stroke frailty was associated with all adverse outcomes assessed, including longer-term mortality (positive association in 6 of 6 studies reporting this outcome; odds ratio: 3.75 [95%CI: 2.41-5.70]), length of admission (3 of 4 studies) and disability (4 of 6 studies).

conclusionsdespite substantial heterogeneity, whichever way it is measured, frailty is common in patients presenting with acute stroke and associated with poor outcomes. This has implications for the design of stroke services and pathways.

Indexed as

FrailtyStrokeAgedFrail ElderlyHumansPrevalenceRisk Factorsdisabilityfrailtymortalityolder peopleprevalencestroke

Identifiers

PMID35352795
PMCPMC9037368
OpenAlexW4214637352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.