ArticleJournal of the American Heart Association2022
Avocado Consumption and Risk of Cardiovascular Disease in US Adults.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Evolving Research Focus on Diet and Cardiovascular Disease: A Systematic Review of 298 Cohort Studies Published from 2019 to 2024.Nutrients · 2025Pooled it
- Exploring avocado consumption and health: a scoping review and evidence map.Frontiers in nutrition · 2025Pooled it
- Substitution of animal-based with plant-based foods on cardiometabolic health and all-cause mortality: a systematic review and meta-analysis of prospective studies.BMC medicine · 2023Pooled it
- Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial.Journal of the American Heart Association · 2022Trial
- Dietary Quality Along a Plant-Based Continuum: The Role of Added Salt, Oil, and Sugar in Chronic Disease Risk.Nutrients · 2026Review
- KetoFLEX 12/3 Diet and Cognitive Health: A Precision-Nutrition Perspective on Mechanisms, Emerging Evidence, and Future Directions.Nutrients · 2026Review
- Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial.The journal of nutrition, health & aging · 2026Article
- Diet, the protective bridge connecting nutrition and cardiovascular health: A review.Food chemistry: X · 2026Review
- Ecological and Human Health Risk Assessment of Metals in Peruvian Avocados Using a Probabilistic Approach.Foods (Basel, Switzerland) · 2025Article
- Global research trends on avocado oil and its fatty acid composition: A bibliometric review.Journal of food and drug analysis · 2025Review
- Bioactive Compounds, Technological Advances, and Sustainable Applications of Avocado (Foods (Basel, Switzerland) · 2025Review
- Effects of Avocado Products on Cardiovascular Risk Factors in Adults: A GRADE-Assessed Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
- Uncovering Causal Links Between Dietary Habits and Cardiovascular Diseases.Food science & nutrition · 2025Article
- Declining Outcrossing Rates Inside Orchard Blocks of 'Maluma' and 'Shepard' Avocado (Plants (Basel, Switzerland) · 2025Article
- Healthful vs. Unhealthful Plant-Based Restaurant Meals.Nutrients · 2025Article
- Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults.Frontiers in public health · 2025Article
- Association between the dietary index for gut microbiota and cardiometabolic multimorbidity: systemic immune-inflammation index and systemic inflammatory response index.Frontiers in nutrition · 2025Article
- The Pulp, Peel, Seed, and Food Products ofInternational journal of molecular sciences · 2024Review
- Substitution of Dairy Products and Risk of Death and Cardiometabolic Diseases: A Systematic Review and Meta-Analysis of Prospective Studies.Current developments in nutrition · 2024Review
- Comprehensive genetic diversity and genome-wide association studies revealed the genetic basis of avocado fruit quality traits.Frontiers in plant science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Background Epidemiologic studies on the relationship between avocado intake and long-term cardiovascular disease (CVD) risk are lacking. Methods and Results This study included 68 786 women from the NHS (Nurses' Health Study) and 41 701 men from the HPFS (Health Professionals Follow-up Study; 1986-2016) who were free of cancer, coronary heart disease, and stroke at baseline. Diet was assessed using validated food frequency questionnaires at baseline and then every 4 years. Cox proportional hazards regressions were used to estimate hazard ratios and 95% CIs. A total of 14 274 incident cases of CVD (9185 coronary heart disease events and 5290 strokes) were documented over 30 years of follow-up. After adjusting for lifestyle and other dietary factors, compared with nonconsumers, those with analysis-specific higher avocado intake (≥2 servings/week) had a 16% lower risk of CVD (pooled hazard ratio, 0.84; 95% CI, 0.75-0.95) and a 21% lower risk of coronary heart disease (pooled hazard ratio, 0.79; 95% CI, 0.68-0.91). No significant associations were observed for stroke. Per each half serving/day increase in avocado intake, the pooled hazard ratio for CVD was 0.80 (95% CI, 0.71-0.91). Replacing half a serving/day of margarine, butter, egg, yogurt, cheese, or processed meats with the equivalent amount of avocado was associated with a 16% to 22% lower risk of CVD. Conclusions Higher avocado intake was associated with lower risk of CVD and coronary heart disease in 2 large prospective cohorts of US men and women. The replacement of certain fat-containing foods with avocado could lead to lower risk of CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.