Evidence map›Paper›PMID 35352278›Full record

ReviewCurrent cardiology reports2022

A Mistake Not to Be Repeated: What Can We Learn from the Underutilization of Statin Therapy for Efficient Dissemination of Cardioprotective Glucose Lowering Agents?

Neil S Maitra, Dhruv Mahtta, Sankar Navaneethan, Elizabeth M Vaughan, Ajar Kochar, Martha Gulati, Glenn N Levine, Laura A Petersen, Salim S Virani

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Impact of GLP-1RA on the Risk of Adverse Liver Outcomes Among Patients With Alcohol-Associated Liver Disease and Type 2 Diabetes.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
  3. Article
  4. Review
  5. Predictors, Disparities, and Facility-Level Variation: SGLT2 Inhibitor Prescription Among US Veterans With CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Neil S MaitraDivision of General Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
Dhruv MahttaSection of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Sankar NavaneethanSection of Nephrology and Institute of Clinical and Translational Research, Baylor College of Medicine, Houston, TX, USA.
Elizabeth M VaughanDivision of General Internal Medicine, Baylor College of Medicine, Houston, TX, USA.
Ajar KocharBrigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA, USA.
Martha GulatiSection of Cardiology, University of Arizona College of Medicine - Phoenix, Phoenix, AR, USA.
Glenn N LevineSection of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Laura A PetersenHealth Policy, Quality & Informatics Program, Michael E. DeBakey VA Medical Center Health Services Research & Development Center for Innovations in Quality, Effectiveness, and Safety, Houston, TX, USA.
Salim S ViraniSection of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA. virani@bcm.edu.ORCID 0000-0001-9541-6954
Michael E. DeBakey VA Medical Center · USBaylor College of Medicine · USBrigham and Women's Hospital · USUniversity of Arizona · US

Funding

Implementing Sustainable Type 2 Diabetes Care: A Hybrid Type 1 RCT to Test a Community Health Worker-Led Evidence-Based InterventionR01DK129474 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Elizabeth M Vaughan · 2021 to 2026
$4.1M
Technology to improve the health of resource-poor Hispanics with diabetesK23DK110341 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI VAUGHAN, ELIZABETH M · 2017 to 2021
$857k
NIDDK NIH HHS K23 DK110341NIDDK NIH HHS R01 DK129474
6 · The paper itself

Abstract

purpose of reviewTo review the factors contributing to underutilization of guideline-directed therapies, identify strategies to alleviate these factors, and apply these strategies for effective and timely dissemination of novel cardioprotective glucose-lowering agents. RECENT

findingsRecent analyses demonstrate underutilization of cardioprotective glucose lowering agents despite guideline recommendations for their use. Major contributors to underutilization of guideline-directed therapies include therapeutic inertia, perceptions about side effects, and factors found at the level of the clinicians, patients, and the healthcare system. The recent emergence of several novel therapies, such as sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, for use in cardiovascular disease provides a unique avenue to improve patient outcomes. To effectively utilize novel cardioprotective glucose lowering agents to improve cardiovascular outcomes, clinicians must recognize and learn from prior barriers to application of guideline-directed therapies. Further endeavors are prudent to ensure uptake of novel agents.

Indexed as

Cardiovascular DiseasesHydroxymethylglutaryl-CoA Reductase InhibitorsSodium-Glucose Transporter 2 InhibitorsCardiotonic AgentsGlucoseHumansHypoglycemic AgentsCardiotonic AgentsGlucoseHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsSodium-Glucose Transporter 2 InhibitorsGlucose-lowering agentsStatinsTherapeutic inertiaUtilization

Identifiers

PMID35352278
OpenAlexW4220780762

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.