Evidence map›Paper›PMID 35352255›Full record

ArticleBulletin of experimental biology and medicine2022

The Role of Cytokines in Maintaining the Dynamics of Cell-Cell Interaction between Natural Killer Cells and Trophoblast Cells.

D O Bazhenov, V A Mikhailova, K L Furaeva, L P Vyaz'mina, D I Sokolov, S A Sel'kov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

D O BazhenovD. O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia. dmitry-bazhenov@mail.ru.
V A MikhailovaD. O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
K L FuraevaD. O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
L P Vyaz'minaD. O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
D I SokolovD. O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
S A Sel'kovD. O. Ott Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia.
Research Institute of Obstetrics and Gynecology named after D.O. Ott · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed the effect of individual cytokines that are secretory products of placenta typical of the uteroplacental bed. The proinflammatory cytokines IL-6, IFNγ, and IL-1β increased the expression of TGFβR2 molecule by trophoblast cells, while VEGF and PLGF increased the expression of CD45, CD29, and CD54 adhesion molecule by trophoblast cells. The antiinflammatory cytokine IL-4 increased LeptinR expression by trophoblast cells. PMA and TNFα also enhanced the adhesion of NK cells to trophoblast cells. Our findings suggest that NK cells involved CD11a, CD11b, and CD18 molecules during their transmigration through trophoblast, as well as during their transendothelial migration.

Indexed as

CytokinesTrophoblastsCell Adhesion MoleculesCell CommunicationFemaleHumansKiller Cells, NaturalPregnancyCell Adhesion MoleculesCytokinesadhesioncytokinescytotoxicitymigrationNK cells

Identifiers

PMID35352255
OpenAlexW4220787160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.