Evidence map›Paper›PMID 35352234›Full record

ArticleJournal of autism and developmental disorders2023

Corpus Callosum Volumes in Children with Autism Spectrum Disorders: Sex-Associated Differences.

Yun Zhang, Bin Qin, Longlun Wang, Ke Zhang, Cui Song, Jie Chen, Jinhua Cai, Tingyu Li

Abstract read
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In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yun ZhangNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Bin QinNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Longlun WangNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Ke ZhangNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Cui SongNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Jie ChenNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Jinhua CaiNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. 664662256@qq.com.
Tingyu LiNational Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. tyli@vip.sina.com.

Funding

Intelligent Medicine Research Project of Chongqing Medical University in 2020 ZHYX202030key project of Chongqing Kewei Joint Medical research project 2018ZDXM008youth project of Chongqing Kewei Joint Medical research project 2018QNXM006
6 · The paper itself

Abstract

This study aimed to analyze the relationship between sex and corpus callosum (CC) volume in children with autism spectrum disorders (ASD) aged 2-4 years. This prospective study included 50 children with ASD and 50 typically developing (TD) children aged 2-4 years. Midsagittal slices of the CCs of the participants were divided into five subregions using FreeSurfer software. The PMCC, AMCC and TCC volumes were significantly higher in ASD participants than in TD participants, and results were significant in females with ASD rather than in males with ASD (all P < 0.05). In toddlers with ASD, the CC volumes were increased and more pronounced in females than in males. This could be due to overgrowth of axons or/and axonal pruning disorders.

Indexed as

Autism Spectrum DisorderCorpus CallosumBrainFemaleHumansMagnetic Resonance ImagingMaleProspective StudiesSex CharacteristicsAutismCorpus callosumMagnetic resonance imaging

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.