Evidence map›Paper›PMID 35352123›Full record

ArticleGlycobiology2022

CarboGrove: a resource of glycan-binding specificities through analyzed glycan-array datasets from all platforms.

Zachary L Klamer, Chelsea M Harris, Jonathan M Beirne, Jessica E Kelly, Jian Zhang, Brian B Haab

Abstract read
In one paragraph

Article in Glycobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  15. A Boltzmann model predicts glycan structures from lectin binding.bioRxiv : the preprint server for biology · 2024
    Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary L KlamerDepartment of Cancer and Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, United States.ORCID 0000-0001-7242-8231
Chelsea M HarrisZ Biotech, Aurora, CO, United States.
Jonathan M BeirneZ Biotech, Aurora, CO, United States.
Jessica E KellyZ Biotech, Aurora, CO, United States.
Jian ZhangZ Biotech, Aurora, CO, United States.
Brian B HaabDepartment of Cancer and Cell Biology, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, United States.

Funding

Detection of Pre-Invasive Pancreatic Cysts Using Protein and Glycan BiomarkersU01CA152653 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI ALLEN, PETER J, BRAND, RANDALL · 2010 to 2021
$5.8M
Subpopulations of Pancreatic Cancer Cells Defined by Glycan MarkersU01CA226158 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI BRAND, RANDALL, HAAB, BRIAN B. · 2019 to 2023
$3.2M
Bioinformatic Tools for Interpretation of Glycan Array DataR44GM131430 · NIGMS · Z BIOTECH, LLC · PI HAAB, BRIAN B., ZHANG, JIAN · 2021 to 2023
$1.6M
Comprehensive Glycoproteomic Tool Development for Cancer BiomarkersR42GM112750 · NIGMS · PROTEIN METRICS, LLC · PI BERN, MARSHALL WAYNE · 2017 to 2019
$947k
NCI NIH HHS U01 CA152653NCI NIH HHS U01 CA226158NIGMS NIH HHS R42 GM112750NIGMS NIH HHS R44 GM131430
6 · The paper itself

Abstract

Glycan arrays continue to be the primary resource for determining the glycan-binding specificity of proteins. The volume and diversity of glycan-array data are increasing, but no common method and resource exist to analyze, integrate, and use the available data. To meet this need, we developed a resource of analyzed glycan-array data called CarboGrove. Using the ability to process and interpret data from any type of glycan array, we populated the database with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies. In meta-analyses of glycan-binding proteins, we observed glycan-binding specificities that were not uncovered from single sources. In addition, we confirmed the ability to efficiently optimize selections of glycan-binding proteins to be used in experiments for discriminating between closely related motifs. Through descriptive reports and a programmatically accessible Application Programming Interface, CarboGrove yields unprecedented access to the wealth of glycan-array data being produced and powerful capabilities for both experimentalists and bioinformaticians.

Indexed as

PolysaccharidesSoftwareDatabases, FactualHumansProteinsPolysaccharidesProteinsbinding specificitydatabaseglycan-binding proteinlectinmicroarray

Identifiers

PMID35352123
PMCPMC9280547

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.