Evidence map›Paper›PMID 35352028›Full record

ReviewNature reviews. Microbiology2022

Tackling the emerging threat of antifungal resistance to human health.

Matthew C Fisher, Ana Alastruey-Izquierdo, Judith Berman, Tihana Bicanic, Elaine M Bignell, Paul Bowyer, Michael Bromley, Roger Brüggemann, Gary Garber, Oliver A Cornely and 10 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 616 papers.

0numbers the graph read from it
0cells of the map it votes in
616citing papers in PubMed
98.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

616 citing papers in PubMed, 1,041 citations in OpenAlex.

  1. Article
  2. Antifungal Dispensing in Denmark: Patterns Across Primary Care, Secondary Care, and Over-the-Counter Sectors.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Repurposing FDA-Approved Drugs to Inhibit Fungal PPTases for Broad-Spectrum Synergy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

556 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 6 countries.

Matthew C FisherMRC Centre for Global Infectious Disease Outbreak Analysis, Imperial College London, London, UK. matthew.fisher@imperial.ac.uk.ORCID http://orcid.org/0000-0002-1862-6402
Ana Alastruey-IzquierdoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.ORCID http://orcid.org/0000-0001-8651-4405
Judith BermanShmunis School of Biomedical and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.ORCID http://orcid.org/0000-0002-8577-0084
Tihana BicanicInstitute of Infection and Immunity, St George's University London, London, UK.ORCID http://orcid.org/0000-0002-2676-838X
Elaine M BignellMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0001-7748-1920
Paul BowyerManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Michael BromleyManchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7611-0201
Roger BrüggemannDepartment of Pharmacy, Radboudumc Institute for Health Sciences and Radboudumc - CWZ Centre of Expertise for Mycology, Radboud University Medical Centre, Nijmegen, Netherlands.
Gary GarberDepartment of Medicine and the School of Public Health and Epidemiology, University of Ottawa, Ottawa, Ontario, Canada.
Oliver A CornelyUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, Germany.ORCID http://orcid.org/0000-0001-9599-3137
Sarah J GurrBiosciences, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0002-4821-0635
Thomas S HarrisonInstitute of Infection and Immunity, St George's University London, London, UK.
Ed KuijperCentre for Infectious Diseases Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
Johanna RhodesMRC Centre for Global Infectious Disease Outbreak Analysis, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1338-7860
Donald C SheppardInfectious Disease in Global Health Program and McGill Interdisciplinary Initiative in Infection and Immunity, McGill University Health Centre, Montreal, Québec, Canada.ORCID http://orcid.org/0000-0001-8877-880X
Adilia WarrisMRC Centre for Medical Mycology, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0001-6586-3358
P Lewis WhitePublic Health Wales Mycology Reference Laboratory, University Hospital of Wales, Cardiff, UK.ORCID http://orcid.org/0000-0003-3056-4205
Jianping XuDepartment of Biology, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-2915-2780
Bas ZwaanDepartment of Plant Science, Laboratory of Genetics, Wageningen University & Research, Wageningen, Netherlands.ORCID http://orcid.org/0000-0002-8221-4998
Paul E VerweijCentre for Infectious Diseases Research, Diagnostics and Laboratory Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands. paul.verweij@radboudumc.nl.ORCID http://orcid.org/0000-0002-8600-9860
University of Exeter · GBImperial College London · GBRadboud University Nijmegen · NLSt George's, University of London · GBUniversity of Manchester · GBInstituto de Salud Carlos III · ESMcGill University Health Centre · CAMcMaster University · CANational Institute for Public Health and the Environment · NLTel Aviv University · ILUniversity Hospital of Wales · GBUniversity of Cologne · DEUniversity of Ottawa · CAWageningen University & Research · NL

Funding

Biotechnology and Biological Sciences Research Council BB/PO18335Biotechnology and Biological Sciences Research Council BB/V017004/1Medical Research Council MR/N006364/2Medical Research Council MR/R015600/1Medical Research Council MR/S001824/1Medical Research Council MR/S001824/2Medical Research Council MR/V033417/1
6 · The paper itself

Abstract

Invasive fungal infections pose an important threat to public health and are an under-recognized component of antimicrobial resistance, an emerging crisis worldwide. Across a period of profound global environmental change and expanding at-risk populations, human-infecting pathogenic fungi are evolving resistance to all licensed systemic antifungal drugs. In this Review, we highlight the main mechanisms of antifungal resistance and explore the similarities and differences between bacterial and fungal resistance to antimicrobial control. We discuss the research and innovation topics that are needed for risk reduction strategies aimed at minimizing the emergence of resistance in pathogenic fungi. These topics include links between the environment and One Health, surveillance, diagnostics, routes of transmission, novel therapeutics and methods to mitigate hotspots for fungal adaptation. We emphasize the global efforts required to steward our existing antifungal armamentarium, and to direct the research and development of future therapies and interventions.

Indexed as

Antifungal AgentsDrug Resistance, FungalAnti-Bacterial AgentsFungiHumansAnti-Bacterial AgentsAntifungal Agents

Identifiers

PMID35352028
PMCPMC8962932
OpenAlexW4220972968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.