ArticlePediatric research2022
Clinical impact of NEC-associated sepsis on outcomes in preterm infants.
Article in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 39 citations in OpenAlex.
- Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.Journal of neonatal-perinatal medicine · 2026Article
- Cardiorespiratory signatures of necrotizing enterocolitis: a 4-NICU study of very low birth weight infants.Pediatric research · 2026Article
- Sepsis in neonates with necrotizing enterocolitis: outcomes and predictive model.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Burden, risk factors, and emerging microbiological trends of Gram-negative neonatal sepsis in Jordan: a retrospective cohort study.BMC infectious diseases · 2026Article
- Clinical impact of early-onset sepsis on outcomes of necrotizing enterocolitis: a retrospective case-control study.BMC pregnancy and childbirth · 2026Article
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- Emerging role of non-coding RNAs as biomarkers and therapeutic targets in preterm infants with necrotizing enterocolitis.Pediatric research · 2026Article
- Identification of the expression of tRNA-derived small RNAs associated with necrotizing enterocolitis.Pediatric research · 2026Article
- Sepsis Associated Necrotizing Enterocolitis (SA-NEC) in Preterm Infants: Risk Factors and Clinical Outcomes.Indian journal of pediatrics · 2026Article
- Adverse neurodevelopment after multiple sepsis and/or necrotizing enterocolitis in preterm infants: revisiting single-episode paradigm.Pediatric research · 2026Article
- Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.Gut microbes · 2025Review
- Development of the preterm infant gut and gastric residuals microbiome.Nature communications · 2025Article
- Distinct microbiota profiles in non-survivors in preterm infants with surgical necrotizing enterocolitis: Insights from FFPE intestinal tissue analysis.Journal of neonatal-perinatal medicine · 2025Article
- The Nonbacterial Infant Microbiome and Necrotizing Enterocolitis.American journal of perinatology · 2025Review
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Impact of Enteral Nutrition on Clinical Outcomes in Very Low Birth Weight Infants in the NICU: A Single-Center Retrospective Cohort Study.Nutrients · 2025Article
- Analysis of risk factors and establishment of predictive models for neonatal necrotizing enterocolitis: a retrospective study.Italian journal of pediatrics · 2025Article
- Ultrasound combined with serological markers for predicting neonatal necrotizing enterocolitis: a machine learning approach.Frontiers in pediatrics · 2025Article
- Necrotizing Enterocolitis-Associated Acute Kidney Injury-Transforming the Paradigm.American journal of perinatology · 2025Review
- Multiple introductions of NRCS-AMicrobial genomics · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo determine risk factors and outcomes of necrotizing enterocolitis (NEC)-associated sepsis in infants with NEC.
methodsA retrospective review comparing demographic and clinical information in infants with and without NEC-associated sepsis (defined as positive blood culture at the time of NEC onset).
resultsA total of 209 infants with medical (n = 98) and surgical NEC (n = 111) had a median gestational age of 27 weeks (IQR 25; 30.5) and a median birth weight of 910 g [IQR 655; 1138]. Fifty of 209 (23.9%) infants had NEC-associated sepsis. Infants with NEC-associated sepsis had lower median GA (26.4 vs. 27.4 weeks; p = 0.01), lower birth weight (745 vs. 930 g; p = 0.009), were more likely mechanically ventilated [p < 0.001], received dopamine [p < 0.001], had more evidence of acute kidney injury [60% vs. 38.4%, p = 0.01], longer postoperative ileus (16 [13.0; 22.0] vs. 12 [8; 16] days; p = 0.006), higher levels of C-reactive protein, lower platelet counts, longer hospitalization compared to infants without NEC-associated sepsis. On multivariate regression, cholestasis was an independent risk factor for NEC-associated sepsis (OR 2.94; 95% CI 1.1-8.8, p = 0.038).
conclusionNEC-associated sepsis was associated with greater hemodynamic support, acute kidney injury, longer postoperative ileus, and hospitalization on bivariate analysis, and cholestasis was associated with higher odds of sepsis on multi regression analysis. IMPACT: NEC-associated sepsis was present in 24% of infants with NEC. Gram-positive bacteria, Gram-negative bacteria, and Candida were found in 15.3%, 10.5%, and 2.8% of cases, respectively. Infants with NEC-associated sepsis had a greater inflammatory response (CRP levels), received more blood transfusion before NEC onset, frequently needed assisted ventilation ionotropic support, and had acute kidney injury after NEC onset. NEC infants with Gram-negative sepsis had higher portal venous gas, received more platelet transfusions before NEC onset, and had higher CRP levels and lower median lymphocyte counts at 24 h after NEC onset than those with Gram-positive sepsis.
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Registered trials
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