ArticleScientific reports2022
Metabolomic serum abnormalities in dogs with hepatopathies.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Altered Serum Concentrations of Fat-Soluble Vitamins in Dogs with Inflammatory Protein-Losing Enteropathy.Animals : an open access journal from MDPI · 2026Article
- A multi-marker NMR metabolomics signature for the superior detection of chronic and acute systemic inflammation in dogs: a comparative study with C-reactive protein.BMC veterinary research · 2026Article
- The Expanding Role of Artificial Intelligence in Companion Animal Care: A Systematic Review.Animals : an open access journal from MDPI · 2026Review
- Preliminary metabolic characterization of hepatic lipidosis in cats using liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry: pathway insights and candidate biomarkers.Journal of veterinary internal medicine · 2026Article
- Evaluation of Free Amino Acid and Fatty Acid Concentrations in Simmental Calves Naturally Infected WithVeterinary medicine international · 2026Article
- Serum Amino Acid Profiles in Dogs with a Congenital Portosystemic Shunt.Metabolites · 2025Article
- Diagnosis and classification of portosystemic shunts: a machine learning retrospective case-control study.Frontiers in veterinary science · 2024Article
- Omics Technologies in Veterinary Medicine: Literature Review and Perspectives in Transfusion Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Serum Amino Acids Imbalance in Canine Chronic Hepatitis: Results in 16 Dogs.Veterinary sciences · 2022Article
- Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Metabolomic Abnormalities in Serum from Untreated and Treated Dogs with Hyper- and Hypoadrenocorticism.Metabolites · 2022Article
- Plasma amino acid profiles of dogs with the hepatocutaneous syndrome and dogs with other chronic liver diseases.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatopathies can cause major metabolic abnormalities in humans and animals. This study examined differences in serum metabolomic parameters and patterns in left-over serum samples from dogs with either congenital portosystemic shunts (cPSS, n = 24) or high serum liver enzyme activities (HLEA, n = 25) compared to control dogs (n = 64). A validated targeted proton nuclear magnetic resonance spectroscopy platform was used to assess 123 parameters. Principal component analysis of the serum metabolome demonstrated distinct clustering among individuals in each group, with the cluster of HLEA being broader compared to the other groups, presumably due to the wider spectrum of hepatic diseases represented in these samples. While younger and older adult control dogs had very similar metabolomic patterns and clusters, there were changes in many metabolites in the hepatopathy groups. Higher phenylalanine and tyrosine concentrations, lower branched-chained amino acids (BCAAs) concentrations, and altered fatty acid parameters were seen in cPSS dogs compared to controls. In contrast, dogs with HLEA had increased concentrations of BCAAs, phenylalanine, and various lipoproteins. Machine learning based solely on the metabolomics data showed excellent group classification, potentially identifying a novel tool to differentiate hepatopathies. The observed changes in metabolic parameters could provide invaluable insight into the pathophysiology, diagnosis, and prognosis of hepatopathies.
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