ArticleNature communications2022
A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Mutation of SCARECROW-LIKE28 or CYTOKININ OXIDASE3/5 suppresses rosette branching in Arabidopsis.Journal of experimental botany · 2026Article
- Dissecting the Cell-Type-Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar-Dependent Involvement of Brassinosteroid Signalling.Plant biotechnology journal · 2026Article
- Article
- The CIN-TCP transcription factors regulate endocycle progression and pavement cell size by promoting cell wall pectin degradation.Nature communications · 2025Article
- RETINOBLASTOMA-RELATED Has Both Canonical and Noncanonical Regulatory Functions During Thermo-Morphogenic Responses in Arabidopsis Seedlings.Plant, cell & environment · 2025Article
- Overexpression ofFrontiers in plant science · 2025Article
- The GRAS transcription factor PtrPAT1 ofHorticulture research · 2025Article
- Article
- A maize semi-dwarf mutant reveals a GRAS transcription factor involved in brassinosteroid signaling.Plant physiology · 2024Article
- MIKC type MADS-box transcription factor LcSVP2 is involved in dormancy regulation of the terminal buds in evergreen perennial litchi (Horticulture research · 2024Article
- CsHLS1-CsSCL28 module regulates compact plant architecture in cucumber.Plant biotechnology journal · 2024Article
- The SIAMESE family of cell-cycle inhibitors in the response of plants to environmental stresses.Frontiers in plant science · 2024Review
- Molecular markers in cell cycle visualisation during development and stress conditions inQuantitative plant biology · 2024Article
- MYB3R-SCL28-SMR module with a role in cell size control negatively regulates G2 progression inPlant signaling & behavior · 2023Article
- High endoreduplication after drought-related conditions in haploid but not diploid mosses.Annals of botany · 2023Article
- MYB3R-mediated and cell cycle-dependent transcriptional regulation of a tobacco ortholog ofPlant biotechnology (Tokyo, Japan) · 2023Article
- The ethylene-responsive transcription factor PpERF9 represses PpRAP2.4 and PpMYB114 via histone deacetylation to inhibit anthocyanin biosynthesis in pear.The Plant cell · 2023Article
- GRAS transcription factors regulate cell division planes in moss overriding the default rule.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of Transcriptome Dynamics during Early Fruit Development in Olive (International journal of molecular sciences · 2023Article
- Integrative analysis of physiology, biochemistry and transcriptome reveals the mechanism of leaf size formation in Chinese cabbage (Frontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 4 countries.
Funding
Abstract
How cell size and number are determined during organ development remains a fundamental question in cell biology. Here, we identified a GRAS family transcription factor, called SCARECROW-LIKE28 (SCL28), with a critical role in determining cell size in Arabidopsis. SCL28 is part of a transcriptional regulatory network downstream of the central MYB3Rs that regulate G2 to M phase cell cycle transition. We show that SCL28 forms a dimer with the AP2-type transcription factor, AtSMOS1, which defines the specificity for promoter binding and directly activates transcription of a specific set of SIAMESE-RELATED (SMR) family genes, encoding plant-specific inhibitors of cyclin-dependent kinases and thus inhibiting cell cycle progression at G2 and promoting the onset of endoreplication. Through this dose-dependent regulation of SMR transcription, SCL28 quantitatively sets the balance between cell size and number without dramatically changing final organ size. We propose that this hierarchical transcriptional network constitutes a cell cycle regulatory mechanism that allows to adjust cell size and number to attain robust organ growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.