Evidence map›Paper›PMID 35351865›Full record

ArticleCell death & disease2022

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies.

Teodora Oltean, Lorena Itati Ibanez, Tatyana Divert, Tine Ysenbaert, Hannelore Van Eeckhoutte, Vera Goossens, Michael Schotsaert, Ken Bracke, Bert Schepens, Jonathan Maelfait and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Efferocytosis and Respiratory Disease.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Teodora OlteanVIB-UGent, Center for Inflammation Research (IRC), Ghent, Belgium.
Lorena Itati IbanezVIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.
Tatyana DivertVIB-UGent, Center for Inflammation Research (IRC), Ghent, Belgium.
Tine YsenbaertVIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.
Hannelore Van EeckhoutteLaboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Vera GoossensVIB Screening Core & UGent Expertise Centre for Bioassay Development and Screening (C-BIOS), Ghent, Belgium.
Michael SchotsaertVIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.ORCID 0000-0003-3156-3132
Ken BrackeLaboratory for Translational Research in Obstructive Pulmonary Diseases, Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Bert SchepensVIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.
Jonathan MaelfaitVIB-UGent, Center for Inflammation Research (IRC), Ghent, Belgium.
Nozomi Takahashi *VIB-UGent, Center for Inflammation Research (IRC), Ghent, Belgium.ORCID 0000-0002-3751-4203
Xavier Saelens *VIB-UGent Center for Medical Biotechnology, VIB, Ghent, Belgium.ORCID 0000-0002-3861-6965
Peter Vandenabeele *VIB-UGent, Center for Inflammation Research (IRC), Ghent, Belgium. Peter.Vandenabeele@irc.vib-ugent.be.ORCID 0000-0002-6669-8822
Ghent University · BEVIB-UGent Center for Inflammation Research · BEGhent University Hospital · BEVIB-UGent Center for Medical Biotechnology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RIPK3 partially protects against disease caused by influenza A virus (IAV) infection in the mouse model. Here, we compared the immune protection of active vaccination with a universal influenza A vaccine candidate based on the matrix protein 2 ectodomain (M2e) and of passive immunization with anti-M2e IgG antibodies in wild type and Ripk3

Indexed as

Influenza A virusInfluenza, HumanInfluenza VaccinesOrthomyxoviridae InfectionsAnimalsAntibodies, ViralHumansImmunization, PassiveImmunoglobulin GMiceMice, Inbred BALB CReceptor-Interacting Protein Serine-Threonine KinasesVaccinationViral Matrix ProteinsAntibodies, ViralImmunoglobulin GInfluenza VaccinesReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humanRipk3 protein, mouseViral Matrix Proteins

Identifiers

PMID35351865
PMCPMC8961492
OpenAlexW4220948072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.