ArticleBMJ case reports2022
Secondary osteonecrosis of the knee as a part of long COVID-19 syndrome: a case series.
Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Osteonecrosis as a manifestation of Long-COVID Syndrome: a systematic review.Musculoskeletal surgery · 2025Pooled it
- The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19.Journal of orthopaedic surgery and research · 2024Pooled it
- Secondary Osteonecrosis of Both Tibial and Femoral Condyles Induced by Dexamethasone Overuse: A Case Report.Cureus · 2025Article
- Knee osteonecrosis after SARS-CoV-2 infection: a systematic case-based review.Annals of joint · 2024Review
- Two Cases of COVID-Related Osteonecrosis of the Jaws: A New and Worrying Entity Is Emerging.World journal of plastic surgery · 2024Article
- Review
- Osteonecrosis amid the COVID-19 pandemic.Rheumatology international · 2023Article
- The painful joint after COVID-19 treatment: A study on joint osteonecrosis following COVID-19-related corticosteroid use.Joint diseases and related surgery · 2023Article
- Steroid-induced osteonecrosis.Journal of translational autoimmunity · 2022Review
- Bisphosphonates for Post-COVID Osteonecrosis of the Femoral Head: Medical Management of a Surgical Condition.JB & JS open accessArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COVID-19 infection affects different organ systems with long-term sequelae, which has been termed as long COVID-19 syndrome. To the best of our knowledge, osteonecrosis of the knee as a part of long COVID-19 syndrome has not been documented. Corticosteroids are being used extensively in moderate and severe cases of COVID-19. We report two cases who developed osteonecrosis of the knee after being treated for COVID-19 infection. In our case series, the mean cumulative dose of prednisolone was 1156.5 mg (900-1413 mg), which is less than the cumulative dose reported in literature for osteonecrosis of the knee. In our case series, the patients developed symptomatic osteonecrosis at a mean interval of 73 days after initiation of steroid therapy, with the earliest presenting at 25 days. Early diagnosis of osteonecrosis of the knee on high clinical suspicion by MRI would help in early intervention with bisphosphonate therapy.
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