Clonal cytopenia of undetermined significance and atypical Behçet's: the importance of zinc.

Patricia Leonard, Alison Louw, David Prentice, Melita Cirillo

Open access · bronzeAbstract readCase Reports

In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Patricia LeonardSchool of Medicine, Curtin University, Bentley, Western Australia, Australia.

Alison LouwMolecular Haematology, PathWest Laboratory Medical WA, Murdoch, Western Australia, Australia.

David PrenticeNeurology, Perron Institute for Neurological and Translational Science, Nedlands, Western Australia, Australia.

Melita CirilloHaematology, Royal Perth Hospital, Perth, Western Australia, Australia melita.cirillo@health.wa.gov.au.ORCID http://orcid.org/0000-0001-9881-0260

Curtin University · AUPathwest Laboratory Medicine · AUPerron Institute for Neurological and Translational Science · AUThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical Behçet's is recognised in myelodysplastic syndrome (MDS) cases and is associated with trisomy 8. Clonal cytopenia of undetermined significance (CCUS) is recognised as a precursor to MDS. Our case describes the presentation of atypical Behçet's, in association with CCUS, post a Streptococcal infection. A mutation of a zinc finger RNA spliceosome, ZRSR2, is also described. Our patient initially presented with macrocytic anaemia, together with neutropenia and lymphocytopenia on routine monitoring. Later gastrointestinal symptoms together with oral and anal ulcerations developed. He was treated with oral zinc therapy and had resolution of recurrent oral ulcerations and significant reduction in severity of anal ulcerations. The functional impact of ZRSR2 mutation on spliceosome assembly is yet to be defined, but has been previously reported in CCUS with a clinical phenotype of macrocytic anaemia.

Indexed as

Anemia, MacrocyticBehcet SyndromeMyelodysplastic SyndromesClonal HematopoiesisHumansMaleZincZincHaematology (incl blood transfusion)ImmunologyInflammatory bowel diseaseMalignant and Benign haematologyVitamins and supplements

Identifiers

PMID35351745

DOI10.1136/bcr-2021-247154

PMCPMC8966545

OpenAlexW4221027467

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.