Evidence map›Paper›PMID 35351710›Full record

ArticleBMJ open2022

Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan.

Keibun Liu, Toru Kotani, Kensuke Nakamura, Takai Chihiro, Yasunari Morita, Kenzo Ishii, Kenji Fujizuka, Daisetsu Yasumura, Daisuke Taniguchi, Tomohiro Hamagami and 20 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 2 countries.

Keibun LiuCritical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia keiliu0406@gmail.com.ORCID 0000-0002-6867-1420
Toru KotaniDepartment of Intensive Care Medicine, Showa University School of Medicine, Tokyo, Japan.
Kensuke NakamuraDepartment of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi, Ibaraki, Japan.
Takai ChihiroDepartment of Emergency Medicine and Critical Care Medicine, Tochigi prefectural emergency and critical care center, Saiseikai Utsunomiya Hospital, Utsunomiya, Tochigi, Japan.
Yasunari MoritaDepartment of Emergency and Intensive Care Medicine, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Kenzo IshiiDepartment of Anesthesiology, Intensive Care Unit, Fukuyama City Hospital, Fukuyama, Hiroshima, Japan.
Kenji FujizukaAdvanced Medical Emergency Department and Critical Care Center, Japan Red Cross Maebashi Hospital, Maebashi, Maebashi, Japan.
Daisetsu YasumuraDepartment of Rehabilitation, Naha City Hospital, Naha, Okinawa, Japan.
Daisuke TaniguchiTajima Emergency & Critical Care Medical Center, Toyooka Public Hospital, Toyooka, Japan.
Tomohiro HamagamiTajima Emergency & Critical Care Medical Center, Toyooka Public Hospital, Toyooka, Japan.
Nobutake ShimojoEmergency and Critical Care Medicine, University of Tsukuba Faculty of Medicine, Tsukuba, Ibaraki, Japan.
Masakazu NittaDepartment of Intensive Care Unit, Niigata University Medical and Dental Hospital, Niigata, Niigata, Japan.
Takashi HongoEmergency Department, Okayama Saiseikai General Hospital, Okayama, Japan.
Kazuki AkiedaDepartment of Emergency Medicine, SUBARU Health Insurance Society Ota Memorial Hospital, Ota, Japan.
Maeda AtsuoDepartment of Emergency and Disaster Medicine, Showa University Fujigaoka Hospital, Yokohama, Kanagawa, Japan.
Tadashi KanekoEmergency and Critical Care Center, Mie University Hospital, Tsu, Mie, Japan.
Yutaka SakudaDepartment of Intensive Care Medicine, Okinawa Kyodo Hospital, Naha, Okinawa, Japan.
Kohkichi AndohDivision of Anesthesiology, Sendai City Hospital, Sendai, Miyagi, Japan.
Akiyoshi NagatomiDepartment of Emergency medicine and Critical Care, St. Marianna University School of Medicine, Yokohama-City Seibu Hospital, Yokohama, Japan.
Yukiko TanakaDepartment of emergency, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, Japan.
Yuhei IrieDepartment of Emergency and Critical care medicine, Fukuoka University Hospital, Fukuoka, Japan.
Hiroshi KamijoIntensive Care Unit, Shinshu University Hospital, Matsumoto, Nagano, Japan.
Manabu HanazawaDepartment of Rehabilitation, Japan Red Cross Narita Hospital, Narita, Japan.
Daisuke KasugaiDepartment of Emergency and Critical Care Medicine, Nagoya University Graduate School of Medicine Faculty of Medicine, Nagoya, Aichi, Japan.
Matsuoka AyakaDepartment of Emergency and Critical Care Medicine Faculty, Saga University Hospital, Saga, Saga, Japan.
Kenji OikeDepartment of Rehabilitation, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan.
Alan Kawarai LeforDepartment of Surgery, Jichi Medical University, Shimotsuke, Japan.
Kunihiko TakahashiM & D Data Science Center, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Hajime KatsukawaJapanese Society for Early Mobilization, Tokyo, Japan.
Takayuki OguraDepartment of Emergency Medicine and Critical Care Medicine, Tochigi prefectural emergency and critical care center, Saiseikai Utsunomiya Hospital, Utsunomiya, Tochigi, Japan.
Naha City Hospital · JPSaiseikai Utsunomiya hospital · JPToyooka Hospital · JPFuji Heavy Industries Health Insurance Society Ota Memorial Hospital · JPFukuoka University Hospital · JPFukuyama City Hospital · JPHitachi General Hospital · JPJapanese Red Cross Narita Hospital · JPJichi Medical University · JPMaebashi Red Cross Hospital · JPMie University Hospital · JPNagoya University · JPNational Hospital Organization · JPNiigata University Medical and Dental Hospital · JPOkayama Saiseikai General Hospital · JPPrince Charles Hospital · AUSaga University · JPSendai City Hospital · JPShinshu University Hospital · JPShowa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSepsis is not only the leading cause of death in the intensive care unit (ICU) but also a major risk factor for physical and cognitive impairment and mental disorders, known as postintensive care syndrome (PICS), reduced health-related quality of life (HRQoL) and even mental health disorders in patient families (PICS-family; PICS-F). The ABCDEF bundle is strongly recommended to overcome them, while the association between implementing the bundle and the long-term outcomes is also unknown. METHODS AND ANALYSIS: This is a multicentre prospective observational study at 26 ICUs. All consecutive patients between 1 November 2020 and 30 April 2022, who are 18 years old or older and expected to stay in an ICU for more than 48 hours due to sepsis or septic shock, are enrolled. Follow-up to evaluate survival and PICS/ PICS-F will be performed at 3, 6 and 12 months and additionally every 6 months up to 5 years after hospital discharge. Primary outcomes include survival at 12 months, which is the primary outcome, and the incidence of PICS defined as the presence of any physical impairment, cognitive impairment or mental disorders. PICS assessment scores, HRQoL and employment status are evaluated. The association between the implementation rate for the ABCDEF bundle and for each of the individual elements and long-term outcomes will be evaluated. The PICS-F, defined as the presence of mental disorders, and HRQoL of the family is also assessed. Additional analyses with data up to 5 years follow-up are planned. ETHICS AND DISSEMINATION: This study received ethics approvals from Saiseikai Utsunomiya Hospital (2020-42) and all other participating institutions and was registered in the University Hospital Medical Information Network Clinical Trials Registry. Informed consent will be obtained from all patients. The findings will be published in peer-reviewed journals and presented at scientific conferences. TRIAL REGISTRATION NUMBER: UMIN000041433.

Indexed as

SepsisShock, SepticAdolescentAdultCritical IllnessHumansIntensive Care UnitsJapanMulticenter Studies as TopicObservational Studies as TopicProspective StudiesQuality of LifeAdult intensive & critical careAnxiety disordersDelirium & cognitive disordersDepression & mood disordersEpidemiologyPAIN MANAGEMENT

Identifiers

PMID35351710
PMCPMC8961143
OpenAlexW4220689867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.