Evidence map›Paper›PMID 35351531›Full record

Trial reportThe Journal of pediatrics2022

Prolonged Cotrimoxazole Prophylaxis Has No Impact on Child Growth in the First Two Years of Life: Findings from a Randomized Controlled Trial in Botswana.

Aamirah Mussa, Kathleen M Powis, Shahin Lockman, Gbolahan Ajibola, Chelsea Morroni, Laura Smeaton, Mompati Mmalane, Joseph Makhema, Roger L Shapiro

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Aamirah MussaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana. Electronic address: amussa@bhp.org.bw.
Kathleen M PowisBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Division of Internal Medicine, Massachusetts General Hospital, Boston, MA; Division of Pediatrics, Massachusetts General Hospital, Boston, MA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.
Shahin LockmanBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA.
Gbolahan AjibolaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Chelsea MorroniBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom.
Laura SmeatonCenter for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA.
Mompati MmalaneBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Joseph MakhemaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Roger L ShapiroBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.
Botswana Harvard AIDS Institute Partnership · BWHarvard University · USBrigham and Women's Hospital · USCancer Research And Biostatistics · USMRC Centre for Reproductive Health · GB

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Short Breastfeeding and Cotrimoxazole among HIV-Exposed Infants in BotswanaR01HD061265 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI LOCKMAN, SHAHIN, SHAPIRO, ROGER L · 2010 to 2015
$4.5M
Training in HIV Genomics, Treatment, and Cure Research in BotswanaD43TW009610 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2013 to 2026
$4.4M
Expansion of research and mentoring to improve birth outcomes and treatment outcomes among HIV-affected children in BotswanaK24AI131924 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Roger L Shapiro · 2018 to 2026
$1.6M
FIC NIH HHS D43 TW009610NIAID NIH HHS K24 AI131924NIAID NIH HHS P30 AI060354NICHD NIH HHS R01 HD061265
6 · The paper itself

Abstract

We investigated the impact of prolonged cotrimoxazole prophylaxis on growth in 2848 HIV-exposed uninfected children enrolled in the Mpepu study, a randomized, placebo-controlled trial in Botswana. No significant differences in mean weight-for-age, length-for-age, or weight-for-length z scores between placebo and cotrimoxazole arms were observed overall through 18 months.

Indexed as

HIV InfectionsTrimethoprim, Sulfamethoxazole Drug CombinationBotswanaChildHumansInfantTrimethoprim, Sulfamethoxazole Drug Combinationantibioticschild growthHIV-exposed uninfected

Identifiers

PMID35351531
PMCPMC9233016
OpenAlexW4220927955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.