Evidence map›Paper›PMID 35351184›Full record

ArticleInfectious agents and cancer2022

HPV types 16/18 L1 E6 and E7 proteins seropositivity and cervical cancer risk in HIV-positive and HIV-negative black South African women.

Mwiza Gideon Singini, Elvira Singh, Debbie Bradshaw, Wenlong Carl Chen, Melitah Motlhale, Abram Bunya Kamiza, Chantal Babb de Villiers, Mazvita Muchengeti, Christopher G Mathew, Robert Newton and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious agents and cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Mwiza Gideon SinginiNational Cancer Registry, National Health Laboratory Service, Sandringham, Johannesburg, South Africa.
Elvira SinghNational Cancer Registry, National Health Laboratory Service, Sandringham, Johannesburg, South Africa. elviras@nicd.ac.za.ORCID http://orcid.org/0000-0003-1259-2122
Debbie BradshawBurden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
Wenlong Carl ChenNational Cancer Registry, National Health Laboratory Service, Sandringham, Johannesburg, South Africa.
Melitah MotlhaleNational Cancer Registry, National Health Laboratory Service, Sandringham, Johannesburg, South Africa.
Abram Bunya KamizaSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Chantal Babb de VilliersDivision of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mazvita MuchengetiNational Cancer Registry, National Health Laboratory Service, Sandringham, Johannesburg, South Africa.
Christopher G MathewSydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Robert NewtonMRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda.
Noemi BenderDivision of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Tim WaterboerDivision of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Freddy SitasBurden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa.
National Health Laboratory Service · ZAGerman Cancer Research Center · DESouth African Medical Research Council · ZAUniversity of the Witwatersrand · ZAKing's College London · GBUniversity of York · GB

Funding

South African Medical Research Council MRC-RFA-SHIP 01- 2015
6 · The paper itself

Abstract

backgroundIn populations with high rates of human immunodeficiency virus (HIV)-coinfection, the nature of the relationship between human papillomavirus (HPV)-16 and -18 (L1, E6 and E7) antibodies and cervical cancer is still uncertain. We measured the association between seropositivity to HPV (L1, E6 and E7) proteins and cervical cancer among black South African women with and without HIV co-infection.

methodsWe used questionnaire data and serum collected from consecutively recruited patients with a newly diagnosed cancer from the Johannesburg Cancer Study from 1346 cervical cancer cases and 2532 controls (diagnosed with other non-infection related cancers). Seropositivity to HPV proteins was measured using a multiplex serological assay based on recombinant glutathione S-transferase (GST) fusion proteins. We measured associations between their presence and cervical cancer using unconditional logistic regression models and evaluated the sensitivity and specificity of these HPV biomarkers.

resultsAmong controls, HIV-negative women from rural areas compared to urban had significantly higher HPV seroprevalence, HPV16 E7 (8.6% vs 3.7%) and HPV18 E7 (7.9% vs 2.0%). HPV16 E6 and E7 antibodies were positively associated with cervical cancer in HIV-positive (Adjusted Odds Ratio (AOR) = 33; 95% CI 10-107) and HIV-negative women (AOR = 97; 95% CI 46-203). In HIV-positive women, HPV E6/E7 antibodies had low sensitivity (43.0%) and high specificity (90.6%) for cervical cancer detection. In HIV-negative women, HPV E6/E7 antibodies sensitivity was 70.6% and specificity was 89.7%.

conclusionsOur data show that HPV (L1, especially E6 and E7) antibody positivity is associated with cervical cancer in both HIV-positive and HIV-negative women. Nonetheless, being HIV-positive plays an important role in the development of cervical cancer.

Indexed as

Cervical cancerE6 and E7, L1 proteinsHuman papillomavirusSeropositivitySouth Africa

Identifiers

PMID35351184
PMCPMC8966297
OpenAlexW4220732002

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.