ArticleReproductive health2022
Fertility treatments and the risk of preterm birth among women with subfertility: a linked-data retrospective cohort study.
Article in Reproductive health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Post-Discharge Trajectories of Romanian Premature Infants: A Cross-Sectional Analysis of Associated Factors.Children (Basel, Switzerland) · 2025Article
- Perinatal health inequalities between Canadian-born and foreign-born women in Canada: a decomposition analysis.BMJ public health · 2025Article
- National-level assessment of gestational carrier pregnancies in the United States.Journal of assisted reproduction and genetics · 2025Article
- Article
- The effect of fertility treatment and socioeconomic status on neonatal and post-neonatal mortality in the United States.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Fertility treatment increases the risk of preterm birth independent of multiple gestations.F&S reports · 2023Article
- Estimating the individual singleton preterm birth risk: nomogram establishment and independent validation.Translational pediatrics · 2023Article
- Exploring the feasibility, acceptability, and preliminary effectiveness of a culturally adapted group prenatal program, CenteringPregnancy, to reduce maternal and infant health disparities among Marshallese Pacific Islanders: A study protocol.Contemporary clinical trials communications · 2023Article
- Eclampsia,Translational pediatrics · 2023Article
- Nomogram for predicting the risk of preterm birth in women undergoing in vitro fertilization cycles.BMC pregnancy and childbirth · 2023Article
- Incidence of complications amongJournal of medicine and life · 2023Article
- Gestational age at birth in pregnancies with antenatal corticosteroid administration in relation to risk factors: a retrospective cohort study.Frontiers in medicine · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundIn vitro fertilization (IVF) births contribute to a considerable proportion of preterm birth (PTB) each year. However, there is no formal surveillance of adverse perinatal outcomes for less invasive fertility treatments. The study objective was to describe associations between fertility treatment (in vitro fertilization, intrauterine insemination, usually with ovulation drugs (IUI), or ovulation drugs alone) and preterm birth, compared to no treatment in subfertile women.
methodsThe Fertility Experiences Study (FES) is a retrospective cohort study conducted at the University of Utah between April 2010 and September 2012. Women with a history of primary subfertility self-reported treatment data via survey and interviews. Participant data were linked to birth certificates and fetal death records to asses for perinatal outcomes, particularly preterm birth.
resultsA total 487 birth certificates and 3 fetal death records were linked as first births for study participants who completed questionnaires. Among linked births, 19% had a PTB. After adjustment for maternal age, paternal age, maternal education, annual income, religious affiliation, female or male fertility diagnosis, and duration of subfertility, the odds ratios and 95% confidence intervals (CI) for PTB were 2.17 (CI 0.99, 4.75) for births conceived using ovulation drugs, 3.17 (CI 1.4, 7.19) for neonates conceived using IUI and 4.24 (CI 2.05, 8.77) for neonates conceived by IVF, compared to women with subfertility who used no treatment during the month of conception. A reported diagnosis of female factor infertility increased the adjusted odds of having a PTB 2.99 (CI 1.5, 5.97). Duration of pregnancy attempt was not independently associated with PTB. In restricting analyses to singleton gestation, odds ratios were not significant for any type of treatment.
conclusionIVF, IUI, and ovulation drugs were all associated with a higher incidence of preterm birth and low birth weight, predominantly related to multiple gestation births.
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