Evidence map›Paper›PMID 35351080›Full record

ArticleBMC oral health2022

Cephalometric measurements performed on CBCT and reconstructed lateral cephalograms: a cross-sectional study providing a quantitative approach of differences and bias.

Benedetta Baldini, Davide Cavagnetto, Giuseppe Baselli, Chiarella Sforza, Gianluca Martino Tartaglia

Abstract read
In one paragraph

Article in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Comparison of conventional two-dimensional and digital three-dimensional imaging in orthodontics : A systematic review and meta-analysis.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
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  7. 2D-to-3D: Predicting three-dimensional (3D) cephalometric measurements from two conventional X-ray images : From 2D to 3D with a computational tool without using computed tomography.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Benedetta Baldini *Facial Surgery and Dentistry Fondazione IRCCS Cà Granda, UOC Maxillo, Ospedale Maggiore Policlinico, 20142, Milan, Italy. benedettabaldini@outlook.it.ORCID 0000-0003-4365-4998
Davide Cavagnetto *Department of Oral and Maxillofacial Surgery, Amsterdam University Medical Center (Amsterdam UMC), Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.ORCID 0000-0001-8573-8327
Giuseppe BaselliDepartment of Electronics, Information and Bioengineering, Politecnico Di Milano, 20133, Milano, Italy.ORCID 0000-0003-2978-1704
Chiarella SforzaFaculty of Medicine and Surgery, Department of Biomedical Sciences for Health, Functional Anatomy Research Center (FARC), Università Degli Studi Di Milano, Milan, Italy.ORCID 0000-0001-6532-6464
Gianluca Martino Tartaglia *Facial Surgery and Dentistry Fondazione IRCCS Cà Granda, UOC Maxillo, Ospedale Maggiore Policlinico, 20142, Milan, Italy.ORCID 0000-0001-7062-5143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCephalometric analysis is traditionally performed on skull lateral teleradiographs for orthodontic diagnosis and treatment planning. However, the skull flattened over a 2D film presents projection distortions and superimpositions to various extents depending on landmarks relative position. When a CBCT scan is indicated for mixed reasons, cephalometric assessments can be performed directly on CBCT scans with a distortion free procedure. The aim of the present study is to compare these two methods for orthodontic cephalometry.

methods114 CBCTs were selected, reconstructed lateral cephalometries were obtained by lateral radiographic projection of the entire volume from the right and left sides. 2D and 3D cephalometric tracings were performed. Since paired t-tests between left and right-side measurements found no statistically significant differences, mean values between sides were considered for both 2D and 3D values. The following measurements were evaluated: PNS-A; S-N; N-Me; N-ANS; ANS-Me; Go-Me; Go-S; Go-Co; SNA, SNB, ANB; BaŜN; S-N^PNS-ANS; PNS-ANS^Go-Me; S-N^Go-Me. Intraclass correlation coefficients, paired t-test, correlation coefficient and Bland-Altman analysis were performed to compare these techniques.

resultsThe values of intra- and inter-rater ICC showed excellent repeatability and reliability: the average (± SD) intraobserver ICCs were 0.98 (± 0.01) and 0.97(± 0.01) for CBCT and RLCs, respectively; Inter-rater reliability resulted in an average ICC (± SD) of 0.98 (± 0.01) for CBCT and 0.94 (± 0.03) for RLC. The paired t-tests between CBCT and reconstructed lateral cephalograms revealed that Go-Me, Go-S, PNS-ANS^Go-Me and S-N^Go-Me measurements were statistically different between the two modalities. All the evaluated sets of measurements showed strong positive correlation; the bias and ranges for the 95% Limits of Agreement showed higher levels of agreement between the two modalities for unpaired measurements with respect to bilateral ones.

conclusionThe cephalometric measurements laying on the mid-sagittal plane can be evaluated on CBCT and used for orthodontic diagnosis as they do not show statistically significant differences with those measured on 2D lateral cephalograms. For measurements that are not in the mid-sagittal plane, the future development of specific algorithms for distortion correction could help clinicians deduct all the information needed for orthodontic diagnosis from the CBCT scan.

Indexed as

Spiral Cone-Beam Computed TomographyCephalometryCone-Beam Computed TomographyCross-Sectional StudiesHumansImaging, Three-DimensionalReproducibility of ResultsAgreementBland–Altman analysisCBCTCephalometric analysisMaxillofacialOrthodonticsThree-dimensional imaging

Identifiers

PMID35351080
PMCPMC8966183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.