Trial reportBMC anesthesiology2022
Comparison of plasma levobupivacaine concentrations with and without epinephrine following erector spinae plane block for breast cancer surgery: a randomized controlled trial.
Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Pharmacokinetic modelling and simulation for prolonged infusion of levobupivacaine with or without epinephrine in transversus abdominis plane and erector spinae plane blocks: a randomised controlled trial and analysis of pooled data.British journal of anaesthesia · 2025Pooled it
- Intercostal nerve blockJournal of thoracic disease · 2026Article
- Ultrasound-Guided Regional Anesthesia: A Narrative Review of Techniques, Safety, and Clinical Applications.Cureus · 2026Review
- Ultrasound-Guided Regional Anesthesia as Primary Analgesic Management in the Orthopedic-Surgical Emergency Department of an Affiliated Hospital: A Retrospective Analysis over a 6-Year Period.Medicina (Kaunas, Lithuania) · 2025Article
- Ultrasound-Guided Regional Block in Renal Transplantation: Towards Personalized Pain Management.Journal of personalized medicine · 2025Article
- Local anesthetic dosing for fascial plane blocks to avoid systemic toxicity: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Review
- Pericapsular Nerve Group (PENG) Associated with Lateral Femoral Cutaneous Nerve (LFCN) Block Versus Fascia Iliaca Compartment Block (FICB) for Total Hip Replacement Surgery: Double-Blind Randomized Controlled Trial.Journal of personalized medicine · 2025Article
- The Utility of Erector Spinae Plane Blocks in Breast Surgery: A Practical Review.Plastic and reconstructive surgery. Global open · 2025Review
- Enhancing recovery in cervical spine surgery with erector spinae plane (ESP) block- A case series.Indian journal of anaesthesia · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe erector spinae plane (ESP) block requires a large volume of local anesthetic to provide effective analgesia, which has the potential to cause local anesthetic systemic toxicity (LAST). Adjunctive epinephrine slows the entry of local anesthetic into the plasma and decreases its toxic effect on vulnerable tissues. We compared plasma levobupivacaine concentrations with and without epinephrine after ESP blocks for breast cancer surgery.
methodsIn this prospective, double-blinded, randomized controlled trial, 35 patients who underwent elective unilateral partial mastectomy with sentinel lymph node biopsy were enrolled. The patients were randomized to group L (ESP block with 2 mg/kg levobupivacaine) or LE (ESP block with 2 mg/kg levobupivacaine and 5 μg/mL epinephrine). Blood samples were obtained at 2.5, 5, 7.5, 10, 12.5, 15, 30, 60, and 120 min after the ESP block, and plasma concentrations of levobupivacaine were compared.
resultsTwenty-nine patients were included in the analysis. The maximum plasma concentration (C
conclusionsA single bolus of 2 mg/kg levobupivacaine in the ESP block resulted in a short T
trial registrationUMIN Clinical Trials Registry, UMIN000034479 . The trial was retrospectively registered on October 13, 2018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.