Evidence map›Paper›PMID 35350922›Full record

ArticleGlobal spine journal2023

Predicting Mechanical Failure Following Cervical Deformity Surgery: A Composite Score Integrating Age-Adjusted Cervical Alignment Targets.

Renaud Lafage, Justin S Smith, Alexandra Soroceanu, Christopher Ames, Peter Passias, Christopher Shaffrey, Gregory Mundis, Basel Sheikh Alshabab, Themistocles Protopsaltis, Eric Klineberg and 6 more

Open access · goldAbstract read
In one paragraph

Article in Global spine journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 2 countries.

Renaud LafageDepartment of Orthopedics, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0002-4820-1835
Justin S SmithDepartment of Neurosurgery, University of Virginia Medical Center, Charlottesville, VA, USA.ORCID 0000-0003-0467-5534
Alexandra SoroceanuDepartment of Surgery, University of Calgary, Calgary, AB, Canada.
Christopher AmesDepartment of Neurological Surgery, University of California, San Francisco, School of Medicine, San Francisco, CA, USA.
Peter PassiasDepartment of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA.
Christopher ShaffreyDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Gregory MundisScripps Clinic, San Diego, CA, USA.
Basel Sheikh AlshababDepartment of Orthopaedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
Themistocles ProtopsaltisDepartment of Orthopedics, NYU Langone Orthopedic Hospital, New York, NY, USA.
Eric KlinebergDepartment of Orthopaedic Surgery, University of California, Davis, CA, USA.
Jonathan ElyseeDepartment of Orthopedics, Hospital for Special Surgery, New York, NY, USA.
Han Jo KimDepartment of Orthopedics, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0003-2170-3592
Shay BessDenver International Spine Center, Presbyterian St. Luke's/Rocky Mountain Hospital for Children, Denver, CO, USA.
Frank SchwabDepartment of Orthopaedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.
Virginie LafageDepartment of Orthopaedic Surgery, Northwell Health, Lenox Hill Hospital, New York, NY, USA.ORCID 0000-0002-0119-7111
International Spine Study Group (ISSG)
Hospital for Special Surgery · USNorthwell Health · USNew York University Langone Orthopedic Hospital · USDuke Medical Center · USRocky Mountain Hospital for Children · USScripps Clinic · USUniversity of Calgary · CAUniversity of California, Davis · USUniversity of California, San Francisco · USUniversity of Virginia Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designRetrospective cohort study.

objectivesInvestigate a composite score to evaluate the relationship between alignment proportionality and risk of distal junctional kyphosis (DJK).

methods84 patients with minimum 1 year follow-up were included (age = 61.1 ± 10.3 years, 64.3% women). The Cervical Score was constructed using offsets from age-adjusted normative values for sagittal vertical axis (SVA), T1 Slope (TS), and TS minus cervical lordosis (CL). Individual points were assigned based on offset with age-adjusted alignment targets and summed to generate the Cervical Score. Rates of mechanical failure (DJK revision or severe DJK [DJK> 20° and ΔDJK> 10°]) were assessed overall and based on Cervical Score. Logistical regressions assessed associations between early radiographic alignment and 1-year failure rate.

resultsMechanical failure rate was 21.4% (N = 18), 10.7% requiring revision. By multivariate logistical regression: 3-month T1S (OR: .935), TS-CL (OR:0.882), and SVA (OR:1.015) were independent predictors of 1-year failure (all P < .05). Cervical Score ranged (-6 to 6), 37.8% of patients between -1 and 1, and 50.0% with 2 or higher. DJK patients had significantly higher Cervical Score (4.1 ± 1.3 vs .6 ± 2.2, P < .001). Patients with a score ≥3 were significantly more likely to develop a failure (71.4%) with OR of 38.55 (95%CI [7.73; 192.26]) and Nagelkerke r2 .524 (P < .001).

conclusionThis study developed a composite alignment score predictive of mechanical failures in CD surgery. A score ≥3 at 3 months following surgery was associated with a marked increase in failure rate. The Cervical Score can be used to analyze sagittal alignment and help define realignment objectives to reduce mechanical failure.

Indexed as

CDcervical deformitydistal junctional kyphosisDJKmechanical failuresagittal alignment

Identifiers

PMID35350922
PMCPMC10538337
OpenAlexW4221029720

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.