Evidence map›Paper›PMID 35350914›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022

Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1-

Kathleen C Schmidt, Inna Loutaev, Thomas V Burlin, Audrey Thurm, Carrie Sheeler, Carolyn Beebe Smith

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kathleen C SchmidtSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Inna LoutaevSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Thomas V BurlinSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Audrey ThurmNeurodevelopmental and Behavioral Phenotyping Service, Office of the Clinical Director, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Carrie SheelerSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Carolyn Beebe SmithSection on Neuroadaptation & Protein Metabolism, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
National Institute of Mental Health · USNational Institutes of Health · US

Funding

Neurodevelopmental and Behavioral Phenotyping ZICMH002961 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THURM, AUDREY · 2017 to 2025
$12.6M
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Fragile X mental retardation protein, a putative translation suppressor, is significantly reduced in FXS. The prevailing hypothesis is that rates of cerebral protein synthesis (rCPS) are increased by the absence of this regulatory protein. We have previously reported increased rCPS in the

Indexed as

CerebrumFragile X SyndromeProtein BiosynthesisAnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1HumansLeucineMaleMiceMice, KnockoutPositron-Emission TomographyYoung AdultFMR1 protein, humanFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1LeucineFMRPFragile X syndromePETprotein synthesistranslation

Identifiers

PMID35350914
PMCPMC9441731
OpenAlexW4220670118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.