Evidence map›Paper›PMID 35350743›Full record

ArticleADMET & DMPK2019

Nicotinic acid in nanocontainers. Encapsulation and release from ion exchangers.

Heinrich Altshuler, Elena Ostapova, Olga Altshuler, Galina Shkurenko, Natalya Malyshenko, Sergey Lyrschikov, Roman Parshkov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ADMET & DMPK, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heinrich AltshulerLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.
Elena OstapovaLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.
Olga AltshulerLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.
Galina ShkurenkoLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.
Natalya MalyshenkoLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.
Sergey LyrschikovLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.
Roman ParshkovLaboratory of Supramolecular Polymer Chemistry, Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch of Russian Academy of Sciences, Kemerovo, 650000, Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The paper is devoted to the study of the ion exchange encapsulation of nicotinic acid in nanocontainers on polymer matrices. Dowex-50 cation exchanger, sulphonated polymer based on metacyclophanoctol, polymer zirconium phosphate, and strongly basic Dowex-1 anion exchanger are used as polymer matrices. It was confirmed that commercial ion exchangers can encapsulate up to 0.64 g of nicotinic acid per gram of polymer. The high elution rate of nicotinic acid from nanocontainers via the ion exchange mechanism makes it possible to achieve the desired pharmacokinetics of drug release in vivo.

Indexed as

encapsulationion exchange polymersnicotinic acidpharmacokinetics

Identifiers

PMID35350743
PMCPMC8957248

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.