ArticleFrontiers in molecular biosciences2022
Applications of Coarse-Grained Models in Metabolic Engineering.
Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Coarse-grained resource allocation modeling for decoding and rewiring microbial metabolism.Trends in microbiology · 2026Review
- GBA Solver: a user-friendly web server for growth balance analysis.Bioinformatics (Oxford, England) · 2025Article
- A Hybrid Soft Sensor Approach Combining Partial Least-Squares Regression and an Unscented Kalman Filter for State Estimation in Bioprocesses.Bioengineering (Basel, Switzerland) · 2025Article
- From flux analysis to self contained cellular models.Frontiers in systems biology · 2025Article
- The evolutionary landscape of prokaryotic chromosome/plasmid balance.Communications biology · 2024Article
- Emergence of Orchestrated and Dynamic Metabolism ofACS synthetic biology · 2024Article
- A coarse-grained bacterial cell model for resource-aware analysis and design of synthetic gene circuits.Nature communications · 2024Article
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Authors and funding
4 authors.
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Abstract
Mathematical modeling is a promising tool for better understanding of cellular processes. In recent years, the development of coarse-grained models has gained attraction since these simple models are able to capture and describe a broad range of growth conditions. Coarse-grained models often comprise only two cellular components, a low molecular component as representative for central metabolism and energy generation and a macromolecular component, representing the entire proteome. A framework is presented that presents a strict mass conservative model for bacterial growth during a biotechnological production process. After providing interesting properties for the steady-state solution, applications are presented 1) for a production process of an amino acid and 2) production of a metabolite from central metabolism.
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