Evidence map›Paper›PMID 35350711›Full record

ArticleBrain communications2021

Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model.

Samantha K Barton, Dario Magnani, Owen G James, Matthew R Livesey, Bhuvaneish T Selvaraj, Owain T James, Emma M Perkins, Jenna M Gregory, Elaine Cleary, C Rosanne M Ausems and 10 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 3 countries.

Samantha K BartonEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0001-7601-0238
Dario MagnaniEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Owen G JamesEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Matthew R LiveseyEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0002-3441-7977
Bhuvaneish T SelvarajEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Owain T JamesEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Emma M PerkinsEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Jenna M GregoryEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0003-3337-4079
Elaine ClearyEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
C Rosanne M AusemsEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Roderick N Carter CarterEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Navneet A VasisthaEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Chen ZhaoEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Karen BurrEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
David StoryEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Alessandra CardinaliEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Nicholas M MortonCentre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4SB, UK.
Giles E HardinghamEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
David J A WyllieEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
Siddharthan ChandranEuan MacDonald Centre for MND, University of Edinburgh, Edinburgh EH16 4SB, UK.
University of Edinburgh · GBMRC Centre for Regenerative Medicine · GBUK Dementia Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oligodendrocytes are implicated in amyotrophic lateral sclerosis pathogenesis and display transactive response DNA-binding protein-43 (TDP-43) pathological inclusions. To investigate the cell autonomous consequences of TDP-43 mutations on human oligodendrocytes, we generated oligodendrocytes from patient-derived induced pluripotent stem cell lines harbouring mutations in the

Indexed as

amyotrophic lateral sclerosisinduced pluripotent stem celloligodendrocytesTDP-43

Identifiers

PMID35350711
PMCPMC8936427
OpenAlexW3208647539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.