ArticleADMET & DMPK2019
Prediction of ADME-Tox properties and toxicological endpoints of triazole fungicides used for cereals protection.
Article in ADMET & DMPK, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- The Complexity of Drug Development: Translational Value and Limitations of Computational ADMET Assays Applied to Approved Anticancer Drugs.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A Systematic Review on the Toxicology of European Union-Approved Triazole Fungicides in Cell Lines and Mammalian Models.Journal of xenobiotics · 2025Review
- Predictions of the Biological Effects of the Main Components of Tarragon Essential Oil.International journal of molecular sciences · 2025Article
- Evaluation of the Aquatic Toxicity of Several Triazole Fungicides.Metabolites · 2024Article
- Evaluation of the Toxicity Potential of the Metabolites of Di-Isononyl Phthalate and of Their Interactions with Members of Family 1 of Sulfotransferases-A Computational Study.Molecules (Basel, Switzerland) · 2023Article
- Predictions of the Biological Effects of Several Acyclic Monoterpenes as Chemical Constituents of Essential Oils Extracted from Plants.Molecules (Basel, Switzerland) · 2023Article
- Assessment of the Effects of Triticonazole on Soil and Human Health.Molecules (Basel, Switzerland) · 2022Article
- Assessment of the Effects of Chitosan, Chitooligosaccharides and Their Derivatives onMolecules (Basel, Switzerland) · 2022Article
- A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole.Molecules (Basel, Switzerland) · 2022Article
- Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis.Medicina (Kaunas, Lithuania) · 2021Article
- Solubility and ADMET profiles of short oligomers of lactic acid.ADMET & DMPK · 2020Article
- Article
- Computational Assessment of the Pharmacological Profiles of Degradation Products of Chitosan.Frontiers in bioengineering and biotechnology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within this study we have considered 9 triazole fungicides that are approved to be used in European Union for protecting cereals: cyproconazole, epoxiconazole, flutriafol, metconazole, paclobutrazole, tebuconazole, tetraconazole, triadimenol and triticonazole. We have summarized the few available data that support their effects on humans and used various computational tools to obtain a widely view concerning their possible harmful effects on humans. The results of our predictive study reflect that all triazole fungicides considered in this study reveal good oral bioavailability, are envisaged as being able to penetrate the blood brain barrier and to interact with P-glycoprotein and with hepatic cytochromes. The predictions concerning the toxicological endpoints for the investigated triazole fungicides reveal that they. reflect potential of skin sensitization, of blockage of the hERG K+ channels and of endocrine disruption, that they have not mutagenic potential and their carcinogenic potential is not clear. Epoxiconazole and triadimenol are predicted to have the highest potentials of producing numerous harmful effects on humans and their use should be avoided or limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.