ArticleIranian journal of biotechnology2021
Transfer and Expression of Native Human Insulin-Like Growth Factor-1 in Tobacco Chloroplasts.
Article in Iranian journal of biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- Construction and optimization of a genetic transformation system for efficient expression of human insulin-GFP fusion gene in flax.Bioresources and bioprocessing · 2024Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Background: Insulin-like growth factor-1 (IGF-1), in addition to having insulin-like effects, has boosting effects on all cells in human body. Most of the recombinant IGF-1 required for patients suffering from its deficiency is currently produced by bacterial and yeast systems. Plant systems, especially chloroplasts, have many benefits for producing human blood proteins. Production costs are low in these systems, and their side effects are less than other systems. Objectives: In this study, the transfer and expression of mature IGF-1 protein cDNA in tobacco chloroplasts under the control of strong plastid transcription and translation elements was evaluated. Materials and Methods: The biolistic transformation method was used to transfer the Results: A truly transformed line was identified from selected seedlings by PCR method. The seed progeny test of 4 Conclusions: Successful transfer and expression of the native human
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