ArticleFrontiers in aging neuroscience2022
Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Serum uric acid and prognosis in acute ischemic stroke: a dose-response meta-analysis of cohort studies.Frontiers in aging neuroscience · 2023Pooled it
- Association of uric acid-to-albumin ratio with diabetic kidney disease: A cross-sectional study.Medicine · 2026Article
- Advances in metabolomics of biomarkers for ischemic stroke: From bench to clinic.Neural regeneration research · 2026Article
- Uric acid, vitamin D, and left ventricular hypertrophy: Unveiling cardiovascular risks - a retrospective cross-sectional study.Medicine · 2026Article
- Association between uric acid to high-density cholesterol ratio (UHR) and in-stent neoatherosclerosis: an optical coherence tomography study.BMC cardiovascular disorders · 2026Article
- Difference in Clinical Features and Risk Factors of Ischemic Stroke Between Young and Elderly Adults: A Retrospective Observation from an Island Population.International journal of general medicine · 2026Article
- Relationship between admission serum uric acid to lymphocyte ratio and the risk of ischemic stroke recurrence and death: a prospective study.Journal of global health · 2025Article
- Correlation between Parkinson's disease subtypes and plasma uric acid/neutrophil-to-lymphocyte ratio.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid.Neuroscience bulletin · 2025Review
- Serum uric acid/creatinine ratio and 1-year stroke recurrence in patient with acute ischemic stroke and abnormal renal function: results from the Xi'an stroke registry study of China.Frontiers in neurology · 2025Article
- Identifying metabolic parameters as key indicators of hyperuricemia and ischemic stroke comorbidity via interpretable Clinlabomics models.Frontiers in endocrinology · 2025Article
- Article
- Risk factors analysis and nomograph model construction of unplanned readmission for ischemic stroke within 31 days in Wenzhou.Frontiers in neurology · 2025Article
- High levels of uric acid upregulate endothelin receptors: the role of MAPK pathways in anArchives of medical science : AMS · 2025Article
- Association of serum uric acid to serum creatinine ratio with 1-year stroke outcomes in patients with acute ischemic stroke: A multicenter observational cohort study.European journal of neurology · 2024Observational
- Serum uric acid: an independent risk factor for cardiovascular disease in Pakistani Punjabi patients.BMC cardiovascular disorders · 2024Observational
- The prognostic value of combined uric acid and neutrophil-to-lymphocyte ratio in acute ischemic stroke patients treated with intravenous thrombolysis.BMC neurology · 2024Article
- Dual effects of serum urate on stroke risk and prognosis: insights from Mendelian randomization.Frontiers in neurology · 2024Article
- Scientific Landscape of Oxidative Stress in Stroke: From a Bibliometric Analysis to an in-Depth Review.Neurochemical research · 2023Review
- Association of serum uric acid to lymphocyte ratio, a novel inflammatory biomarker, with risk of stroke: A prospective cohort study.CNS neuroscience & therapeutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Serum uric acid (UA) has been reported to be associated with ischemic stroke and inflammation. However, whether or not UA is related to the recurrence of ischemic stroke, and whether inflammation plays a role in the relationship between them remain inconclusive. Objective: We sought to explore the relationship between UA and the recurrence of ischemic stroke and to define the role of neutrophil-to-lymphocyte ratio (NLR) in the aforementioned relationship. Methods: A total of 8,995 patients were included in this study. Basic information and blood samples were collected, and whether or not each participant experienced ischemic stroke recurrence within 3 years was documented. Patients were stratified into three groups according to their UA level, as follows: ≤ 266, 267-339, and ≥ 340 μmol/L. COX regression and restricted cubic spline regression models were used to evaluate the clinical correlation between UA and ischemic stroke recurrence, mediation analysis and interaction and joint analysis were used to evaluate the role of NLR in the association of UA and ischemic stroke recurrence, and sensitivity and subgroup analyses were performed to test the robustness of the data. Results: Ischemic stroke recurrence was related to male sex, older age, higher UA level, higher NLR, hypertension, diabetes, and cardiovascular disease. Following adjustment for potential confounders, a high level of UA (≥ 340 μmol/L) increased the risk of recurrence by 92.6% in patients with previous ischemic stroke. We also found that NLR affects the association between UA and the recurrence of ischemic stroke in older adults, suggesting that patients with high NLR and high UA levels are at greater risk for ischemic stroke recurrence. Conclusion: UA level is non-linearly associated with recurrence, and NLR has an additive interaction between UA and ischemic stroke recurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.