Evidence map›Paper›PMID 35350586›Full record

ArticleNetwork neuroscience (Cambridge, Mass.)2022

A regression framework for brain network distance metrics.

Chal E Tomlinson, Paul J Laurienti, Robert G Lyday, Sean L Simpson

Abstract read
In one paragraph

Article in Network neuroscience (Cambridge, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Connectivity Regression.Biostatistics (Oxford, England) · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Statistical Brain Network Analysis.Annual review of statistics and its application · 2024
    Article
  9. Article
  10. Observational
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chal E TomlinsonDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0003-4322-930X
Paul J LaurientiLaboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Robert G LydayLaboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sean L SimpsonLaboratory for Complex Brain Networks, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Analytical Tools for Complex Brain Networks: Fusing Novel Statistical Methods and Network Science to Understand Brain FunctionR01EB024559 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIMPSON, SEAN L · 2018 to 2021
$1.5M
NCATS NIH HHS UL1 TR001420NIBIB NIH HHS R01 EB024559
6 · The paper itself

Abstract

Analyzing brain networks has long been a prominent research topic in neuroimaging. However, statistical methods to detect differences between these networks and relate them to phenotypic traits are still sorely needed. Our previous work developed a novel permutation testing framework to detect differences between two groups. Here we advance that work to allow both assessing differences by continuous phenotypes and controlling for confounding variables. To achieve this, we propose an innovative regression framework to relate distances (or similarities) between brain network features to functions of absolute differences in continuous covariates and indicators of difference for categorical variables. We explore several similarity metrics for comparing distances (or similarities) between connection matrices, and adapt several standard methods for estimation and inference within our framework: standard

Indexed as

ConnectivityfMRIGraph theoryJaccardKolmogorov–SmirnovNeuroimagingSmall-world

Identifiers

PMID35350586
PMCPMC8942614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.