ArticleFrontiers in medicine2022
Effect of Serum Phosphate on the Prognosis of Septic Patients: A Retrospective Study Based on MIMIC-IV Database.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of serum phosphate levels in sepsis: a systematic review and meta-analysis.PeerJ · 2023Pooled it
- Development and validation of machine learning models to predict in-hospital mortality in ICU patients with sepsis and chronic kidney disease.BMC infectious diseases · 2025Article
- Association between serum phosphate levels and 28-day mortality in patients with sepsis-associated liver injury: a cohort study.BMC infectious diseases · 2025Article
- Relationship between time-weighted average anion gap and mortality in septic shock patients: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- Change trends in serum phosphate levels predict in-hospital mortality in critically ill septic patients.Scientific reports · 2025Article
- Effect of changes trajectory of serum phosphate levels on the 28-day mortality risk in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.BMC infectious diseases · 2025Article
- Targeting serum phosphate trajectory stratification to improve outcomes in high-risk Cardiovascular-Kidney-Metabolic-Sepsis cohorts.PloS one · 2025Article
- The U-shaped association between initial serum phosphate level and mortality of traumatic brain injury patients.Frontiers in neurology · 2025Article
- Effect of early serum phosphate disorder on in-hospital and 28-day mortality in sepsis patients: a retrospective study based on MIMIC-IV database.BMC medical informatics and decision making · 2024Article
- Serum phosphate levels and the development of sepsis associated acute kidney injury: evidence from two independent databases.Frontiers in medicine · 2024Article
- Correlation between serum phosphate and all-cause mortality in critically ill patients with coronary heart disease accompanied by chronic kidney disease: a retrospective study using the MIMIC-IV database.Frontiers in cardiovascular medicine · 2024Article
- Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database.Scientific reports · 2023Article
- A nomogram for predicting sepsis-associated delirium: a retrospective study in MIMIC III.BMC medical informatics and decision making · 2023Article
- Elevated Initial Serum Phosphate Levels Predict Higher Mortality and Impaired Neurological Outcome in Cardiac Arrest Patients with Return of Spontaneous Circulation.Diagnostics (Basel, Switzerland) · 2023Article
- Establishment of a Simple Pediatric Lower Respiratory Tract Infections Database Based on the Structured Electronic Medical Records.Frontiers in pediatrics · 2022Article
- Day-Specific Associations of Serum Phosphate With 90-Day Mortality in Adult Patients With sepsis: A Landmark Analysis.Acute medicine & surgeryArticle
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3 authors.
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Abstract
Objective: To assess the effect of serum inorganic phosphate (Pi) on the prognosis of patients with sepsis. Methods: A retrospective analysis of patients with sepsis selected from the Medical Information Mart for Intensive Care (MIMIC)-IV database was performed. Sepsis was diagnosed according to the Third International Consensus Definition for sepsis and septic shock (Sepsis-3). The time-weighted values of the serum Pi measurements within the first 24 h of sepsis were analyzed. The association between serum Pi and in-hospital mortality was evaluated with a generalized linear model (log-binomial model). Results: The analysis of 11,658 patients from six intensive care units (ICUs) showed a nearly linear correlation between serum Pi and in-hospital mortality in all patients with sepsis, especially in those with acute kidney injury (AKI). The increase of serum Pi was related to a higher risk of AKI, higher norepinephrine doses, ICU mortality, and in-hospital mortality. The generalized linear model showed that serum Pi was an independent predictor for in-hospital mortality in all patients with sepsis even within the normal range. The adjusted risk ratios (RRs) were also significant in subgroup analyses according to kidney function, gender, respiratory infection, vasopressor use, and Sequential Organ Failure Assessment (SOFA) score. Conclusion: Higher levels of serum Pi, even within the normal range, were significantly associated with a higher risk of in-hospital mortality in patients with sepsis regardless of kidney function, gender, respiratory infection, vasopressor use, and SOFA score.
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