ArticleFrontiers in veterinary science2022
Runs of Homozygosity Uncover Potential Functional-Altering Mutation Associated With Body Weight and Length in Two Duroc Pig Lines.
Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- Genomic inbreeding and runs of homozygosity in Mexican Coreño Creole cattle.Tropical animal health and production · 2026Article
- Integrative multi-omics analysis of growth plate regulation underlying body size in miniature pigs.Communications biology · 2026Article
- Characterization of genomic diversity and population structure of worldwide Duroc subpopulations and other pig breeds.Genetics, selection, evolution : GSE · 2025Article
- Multi-dimensional annotation of porcine variants using genomic and epigenomic features in pigs.BMC biology · 2025Article
- The CNV map construction and ROH analysis of Pinan cattle.BMC genomics · 2025Article
- Integrated analysis of the DNA methylome and RNA transcriptome during the development of skeletal muscle in Duroc pigs.BMC genomics · 2024Article
- Selective Sweeps in the Austrian Turopolje and Other Commercial Pig Populations.Animals : an open access journal from MDPI · 2023Article
- Assessment and Distribution of Runs of Homozygosity in Horse Breeds Representing Different Utility Types.Animals : an open access journal from MDPI · 2022Article
- Insights into the architecture of human-induced polygenic selection in Duroc pigs.Journal of animal science and biotechnology · 2022Article
- Identification of Homozygous Regions With Adverse Effects on the Five Economic Traits of Duroc Pigs.Frontiers in veterinary science · 2022Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Runs of homozygosity (ROH) are widely used to investigate genetic diversity, demographic history, and positive selection signatures of livestock. Commercial breeds provide excellent materials to reveal the landscape of ROH shaped during the intense selection process. Here, we used the GeneSeek Porcine 50K single-nucleotide polymorphism (SNP) Chip data of 3,770 American Duroc (AD) and 2,096 Canadian Duroc (CD) pigs to analyze the genome-wide ROH. First, we showed that AD had a moderate genetic differentiation with CD pigs, and AD had more abundant genetic diversity and significantly lower level of inbreeding than CD pigs. In addition, sows had larger levels of homozygosity than boars in AD pigs. These differences may be caused by differences in the selective intensity. Next, ROH hotspots revealed that many candidate genes are putatively under selection for growth, sperm, and muscle development in two lines. Population-specific ROHs inferred that AD pigs may have a special selection for female reproduction, while CD pigs may have a special selection for immunity. Moreover, in the overlapping ROH hotspots of two Duroc populations, we observed a missense mutation (rs81216249) located in the growth and fat deposition-related supergene (
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