Evidence map›Paper›PMID 35350378›Full record

ReviewFrontiers in cell and developmental biology2022

Roles of RNA Modifications in Diverse Cellular Functions.

Emma Wilkinson, Yan-Hong Cui, Yu-Ying He

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Blood N1-methyladenosine (mCritical care (London, England) · 2026
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  7. Article
  8. Review
  9. Review
  10. Article
  11. Influenza NS1 drives NEmerging microbes & infections · 2025
    Article
  12. Review
  13. Review
  14. Dynamic eIF3-S6 Phase Separation Switch Instructed by mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Article
  16. Targeting RNA adenosine editing and modification enzymes for RNA therapeutics.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  17. Review
  18. Article
  19. Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emma WilkinsonDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, United States.
Yan-Hong CuiDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, United States.
Yu-Ying HeDepartment of Medicine, Section of Dermatology, University of Chicago, Chicago, IL, United States.
University of Chicago · US

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Multi-Disciplinary Training Grant in Cancer ResearchT32CA009594 · NCI · UNIVERSITY OF CHICAGO · PI KAY F MACLEOD, Scott A. Oakes · 1989 to 2026
$11.5M
YTHDF2 and UVB damage response in skin cancerR01ES024373 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2015 to 2023
$4.3M
The mechanistic role of METTL14 in UVB-induced skin tumorigenesisR01ES030576 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2019 to 2023
$3.0M
FTO and RNA methylation in arsenic tumorigenicityR01ES031534 · NIEHS · UNIVERSITY OF CHICAGO · PI HE, YU-YING · 2020 to 2022
$1.2M
NCATS NIH HHS UL1 TR000430NCI NIH HHS T32 CA009594NIEHS NIH HHS R01 ES024373NIEHS NIH HHS R01 ES030576NIEHS NIH HHS R01 ES031534
6 · The paper itself

Abstract

Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The deposition and function of these modifications are mediated by the actions of writer, reader, and eraser proteins. At the cellular level, RNA modifications regulate several cellular processes including cell death, proliferation, senescence, differentiation, migration, metabolism, autophagy, the DNA damage response, and liquid-liquid phase separation. Emerging evidence demonstrates that RNA modifications play active roles in the physiology and etiology of multiple diseases due to their pervasive roles in cellular functions. Here, we will summarize recent advances in the regulatory and functional role of RNA modifications in these cellular functions, emphasizing the context-specific roles of RNA modifications in mammalian systems. As m

Indexed as

cellular functionsepitranscriptomicsm1Am5Cm6Atherapeutics

Identifiers

PMID35350378
PMCPMC8957929
OpenAlexW4220898336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.