Evidence map›Paper›PMID 35350351›Full record

ArticleACS omega2022

Observation of Arginine Side-Chain Motions Coupled to the Global Conformational Exchange Process in Deubiquitinase A.

Ashish Kabra, Efsita Rumpa, Ying Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashish KabraDepartment of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, Kentucky 40208, United States.
Efsita RumpaDepartment of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, Kentucky 40208, United States.
Ying LiDepartment of Chemistry, University of Louisville, 2320 South Brook Street, Louisville, Kentucky 40208, United States.ORCID https://orcid.org/0000-0001-7678-9405

Funding

Structural Mechanisms Underlying Regulation and Substrate Specificity of Deubiquitinase AR15GM123391 · NIGMS · UNIVERSITY OF LOUISVILLE · PI LI, YING · 2018 to 2018
$455k
NIGMS NIH HHS R15 GM123391
6 · The paper itself

Abstract

Coupled motions have been demonstrated to be functionally important in a number of enzymes. Noncovalent side-chain interactions play essential roles in coordinating the motions across different structural elements in a protein. However, most of the dynamic studies of proteins are focused on backbone amides or methyl groups in the side chains and little is known about the polar and charged side chains. We have previously characterized the conformational dynamics of deubiquitinase A (DUBA), an isopeptidase, on the microsecond-to-millisecond (μs-ms) time scales with the amide

Identifiers

PMID35350351
PMCPMC8945143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.