Evidence map›Paper›PMID 35350174›Full record

ArticleOpen forum infectious diseases2022

Novel Combination Therapy for Extensively Drug-Resistant

Dana J Holger, Ashlan J Kunz Coyne, Jing J Zhao, Avnish Sandhu, Hossein Salimnia, Michael J Rybak

Open access · goldAbstract readCase Reports
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  2. Successful Treatment of Carbapenem-ResistantInfection and drug resistance · 2026
    Article
  3. Antimicrobial agents and chemotherapy · 2025
    Review
  4. Article
  5. Review
  6. Sulbactam for carbapenem-resistantJAC-antimicrobial resistance · 2025
    Review
  7. Successful Treatment of OXA-23Infection and drug resistance · 2025
    Article
  8. The challenges of difficult-to-treatClinical microbiology reviews · 2024
    Review
  9. Antibiotic Treatment of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Article
  12. Treatment of infections caused by carbapenem-resistantFrontiers in cellular and infection microbiology · 2024
    Review
  13. Review
  14. In Vivo Emergence of Pandrug-ResistantOpen forum infectious diseases · 2023
    Article
  15. Article
  16. Navigating Available Treatment Options for Carbapenem-Resistant Acinetobacter baumannii-calcoaceticus Complex Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dana J HolgerAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Ashlan J Kunz CoyneAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
Jing J ZhaoDepartment of Pharmacy, Harper University Hospital, Detroit Medical Center, Detroit, Michigan, USA.
Avnish SandhuDetroit Receiving Hospital, Detroit Medical Center, Detroit, Michigan, USA.
Hossein SalimniaDetroit Medical Center University Laboratories, Detroit, Michigan, USA.
Michael J RybakAnti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0003-2220-0081
Eugene Applebaum College of Pharmacy and Health Sciences · USDetroit Medical Center · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report our clinical and laboratory experience treating a 50-year-old patient who was critically ill with extensively drug-resistant

Indexed as

Acinetobacter baumanniiantimicrobial resistancecombination therapypneumoniasulbactam–durlobactam

Identifiers

PMID35350174
PMCPMC8946682
OpenAlexW4221089565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.