Evidence map›Paper›PMID 35350074›Full record

ArticleAesthetic surgery journal2022

Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis.

Darren B Abbas, Christopher V Lavin, Evan J Fahy, Michelle Griffin, Nicholas J Guardino, Rahim S Nazerali, Dung H Nguyen, Arash Momeni, Michael T Longaker, Derrick C Wan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aesthetic surgery journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Darren B AbbasDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5218-1665
Christopher V LavinDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Evan J FahyDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Michelle GriffinDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Nicholas J GuardinoDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Rahim S NazeraliDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Dung H NguyenDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Arash MomeniDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Michael T LongakerDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Derrick C WanDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatments for radiation-induced fibrosis range from vitamin E (VE) and pentoxifylline (PTX) systemically to deferoxamine and fat grafting locally. Regarding fat grafting, volume retention hinders its long-term functionality and is affected by 2 factors: inflammation and necrosis secondary to hypovascularity.

objectiveThe authors aimed to simultaneously improve fat graft retention and radiation-induced fibrosis by integrating VE and PTX into fat grafts locally.

methodsForty adult CD-1 nude male mice, 6 weeks old, underwent scalp irradiation and recovered for 4 weeks to allow for development of fibrosis. Mice received 200 μL of donor human fat graft to the scalp. Mice were separated into 4 conditions: no grafting, fat graft without treatment, graft treated with PTX, and graft treated with VE. Fat graft volume retention was monitored in vivo with micro-computed tomography scans at weeks 0, 1, 2, 4, 6, and 8 after grafting. Histological and cytokine analysis of the scalp skin and fat grafts were performed.

resultsVE-treated grafts had significant improvement in dermal thickness and collagen density of overlying skin compared with all other groups. VE decreased 8-isoprostane and increased CD31+ staining compared with the other grafted groups. Cytokine analysis revealed decreased inflammatory and increased angiogenic markers in both the fat graft and overlying skin of the VE group. Fat graft volume retention was significantly improved in the VE group starting at 1 week post grafting.

conclusionsRadiation-induced fibrosis and fat graft volume retention are both simultaneously improved with local administration of VE.

Indexed as

Adipose TissueGraft SurvivalAnimalsCytokinesHumansMaleMiceMice, NudeRadiation Fibrosis SyndromeVitamin EX-Ray MicrotomographyCytokinesVitamin E

Identifiers

PMID35350074
PMCPMC9342682
OpenAlexW4220900260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.