Evidence map›Paper›PMID 35349784›Full record

ArticleNeuron2022

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine.

Lite Yang, Mengyi Xu, Shamsuddin A Bhuiyan, Jia Li, Jun Zhao, Randall J Cohrs, Justin T Susterich, Sylvia Signorelli, Ursula Green, James R Stone and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed
25.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 181 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. A Tac1-Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Review
  19. MDFIC2 is a sensory neuron-specific PIEZO channel auxiliary subunit.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Article

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Lite YangDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mengyi XuDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Shamsuddin A BhuiyanDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jia LiDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jun ZhaoDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.
Randall J CohrsDepartments of Neurology and Immunology/Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Justin T SusterichDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Sylvia SignorelliDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Ursula GreenDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
James R StoneDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Dan LevyDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA.
Jochen K LennerzDepartment of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
William RenthalDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: wrenthal@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · USUniversity of Colorado Denver · US

Funding

Next Generation Gene Therapy for Refractory PainR01NS119476 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI William Russell Renthal · 2022 to 2026
$3.4M
MECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORSR01NS078263 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEVY, DAN · 2013 to 2022
$3.1M
Epigenomic labeling of cells that drive drug abuse behaviorDP1DA054343 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI RENTHAL, WILLIAM RUSSELL · 2021 to 2025
$2.7M
Cortical-Meningeal Interactions Underlying Migraine HeadacheR01NS115972 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DAN LEVY · 2021 to 2026
$2.3M
CONTROL OF LONG GENE EXPRESSION AS A NOVEL THERAPEUTIC APPROACH FOR RETT SYNDROMEK08NS101064 · NINDS · HARVARD MEDICAL SCHOOL · PI RENTHAL, WILLIAM RUSSELL · 2017 to 2021
$940k
NIDA NIH HHS DP1 DA054343NINDS NIH HHS K08 NS101064NINDS NIH HHS R01 NS078263NINDS NIH HHS R01 NS115972NINDS NIH HHS R01 NS119476
6 · The paper itself

Abstract

Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are involved remain unclear. We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. These data describe evolutionarily conserved and human-specific gene expression patterns within each trigeminal ganglion cell type, as well as the transcription factors and gene regulatory elements that contribute to cell-type-specific gene expression. We then leveraged these data to identify trigeminal ganglion cell types that are implicated both by human genetic variation associated with migraine and two mouse models of headache. This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain.

Indexed as

Migraine DisordersTrigeminal GanglionAnimalsDisease Models, AnimalHeadacheHumansMiceNeuronsepigenomicsfacial paingene regulationheadachemigrainesingle-cell genomicstrigeminal ganglion

Identifiers

PMID35349784
PMCPMC9338779
OpenAlexW4220688905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.