ArticleDiabetes care2022
Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study.
Article in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Causal relationship between nonalcoholic fatty liver disease and different sleep traits: a bidirectional Mendelian randomized study.Frontiers in endocrinology · 2023Trial
- Management of type 2 diabetes, 2026. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).Diabetologia · 2026Article
- Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non-Diabetic Hyperglycaemia.Journal of sleep research · 2026Article
- Insomnia in Type 2 Diabetes Mellitus: Prevalence, Psychological Correlates, and Association With Glycemic Control.Cureus · 2026Article
- From yawn to dawn: the effects of a sleep extension intervention on objective and subjective dimensions of sleep health in adults with habitual short sleep duration.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Clinical utility of self-reported sleep duration and insomnia symptoms in type 2 diabetes prediction.Diabetologia · 2025Article
- Factors associated with sleep duration in a Chinese middle-aged and elderly diabetic population: a cross-sectional study.Acta diabetologica · 2025Article
- Chronic Insomnia and Stroke Risk-A Real Bidirectional Issue.Life (Basel, Switzerland) · 2025Review
- Comparative cardiovascular outcomes and safety of hypoglycemic drug classes in patients with type 2 diabetes and hypertension: a multicenter cohort analysis.Cardiovascular diabetology · 2025Article
- Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses.Diabetology & metabolic syndrome · 2025Article
- Continuous glucose monitoring in adults with short bowel syndrome receiving overnight infusions of home parenteral nutrition.European journal of clinical nutrition · 2025Article
- The impact of sleep on breast cancer-specific mortality: a Mendelian randomisation study.BMC cancer · 2025Article
- Mendelian randomization studies on the causal relationship between insomnia and disease.Frontiers in medicine · 2025Review
- Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies.Current sleep medicine reports · 2025Article
- Evaluating causal associations of chronotype with pregnancy and perinatal outcomes and its interactions with insomnia and sleep duration: a mendelian randomization study.BMC pregnancy and childbirth · 2024Article
- Sleep extension and cardiometabolic health: what it is, possible mechanisms and real-world applications.The Journal of physiology · 2024Review
- Disease Modules Associated with Unfavorable Sleep Patterns and Their Genetic Determinants: A Prospective Cohort Study of the UK Biobank.Phenomics (Cham, Switzerland) · 2024Article
- Temporal Relationship between HbA1c and Depressive Symptom Trajectories in a Longitudinal Cohort Study: The Mediating Role of Healthy Lifestyles.Brain sciences · 2024Article
- Personal light exposure patterns and incidence of type 2 diabetes: analysis of 13 million hours of light sensor data and 670,000 person-years of prospective observation.The Lancet regional health. Europe · 2024Article
- The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 4 countries.
Funding
Abstract
objectiveTo examine the effects of sleep traits on glycated hemoglobin (HbA1c). RESEARCH DESIGN AND
methodsThis study triangulated evidence across multivariable regression (MVR) and one- (1SMR) and two-sample Mendelian randomization (2SMR) including sensitivity analyses on the effects of five self-reported sleep traits (i.e., insomnia symptoms [difficulty initiating or maintaining sleep], sleep duration, daytime sleepiness, napping, and chronotype) on HbA1c (in SD units) in adults of European ancestry from the UK Biobank (for MVR and 1SMR analyses) (n = 336,999; mean [SD] age 57 [8] years; 54% female) and in the genome-wide association studies from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) (for 2SMR analysis) (n = 46,368; 53 [11] years; 52% female).
resultsAcross MVR, 1SMR, 2SMR, and their sensitivity analyses, we found a higher frequency of insomnia symptoms (usually vs. sometimes or rarely/never) was associated with higher HbA1c (MVR 0.05 SD units [95% CI 0.04-0.06]; 1SMR 0.52 [0.42-0.63]; 2SMR 0.24 [0.11-0.36]). Associations remained, but point estimates were somewhat attenuated after excluding participants with diabetes. For other sleep traits, there was less consistency across methods, with some but not all providing evidence of an effect.
conclusionsOur results suggest that frequent insomnia symptoms cause higher HbA1c levels and, by implication, that insomnia has a causal role in type 2 diabetes. These findings could have important implications for developing and evaluating strategies that improve sleep habits to reduce hyperglycemia and prevent diabetes.
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Registered trials
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