ArticleCerebral cortex (New York, N.Y. : 1991)2023
Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Cortical folding and thickness characteristics of gray matter in fetuses with non-severe ventriculomegaly.BMC pediatrics · 2026Article
- Mapping Fetal Brain Development of 10 Weeks' Gestational Age with 9.4T Postmortem MRI and Histologic Sections.AJNR. American journal of neuroradiology · 2025Article
- Current Diagnostic, Counseling, and Treatment Options in Non-Severe and Severe Apparently Isolated Fetal Ventriculomegaly.Biomedicines · 2024Review
- Isolated Fetal Ventriculomegaly: Diagnosis and Treatment in the Prenatal Period.Children (Basel, Switzerland) · 2024Review
- Divergent growth of the transient brain compartments in fetuses with nonsyndromic isolated clefts involving the primary and secondary palate.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Chromosomal Abnormalities Detected by Chromosomal Microarray Analysis and Karyotype in Fetuses with Ultrasound Abnormalities.International journal of general medicine · 2024Article
- Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- BOUNTI: Brain vOlumetry and aUtomated parcellatioN for 3D feTal MRI.bioRxiv : the preprint server for biology · 2023Article
- A neural stem cell paradigm of pediatric hydrocephalus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Characterisation of ASD traits among a cohort of children with isolated fetal ventriculomegaly.Nature communications · 2023Article
- Abnormal prenatal brain development in Chiari II malformation.Frontiers in neuroanatomy · 2023Article
- 3D black blood cardiovascular magnetic resonance atlases of congenital aortic arch anomalies and the normal fetal heart: application to automated multi-label segmentation.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Article
- Fetal Neurology: From Prenatal Counseling to Postnatal Follow-Up.Diagnostics (Basel, Switzerland) · 2022Review
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
Abstract
Mild isolated fetal ventriculomegaly (iFVM) is the most common abnormality of the fetal central nervous system. It is characterized by enlargement of one or both of the lateral ventricles (defined as ventricular width greater than 10 mm, but less than 12 mm). Despite its high prevalence, the pathophysiology of iFVM during fetal brain development and the neurobiological substrate beyond ventricular enlargement remain unexplored. In this work, we aimed to establish the relationships between the structural development of transient fetal brain zones/compartments and increased cerebrospinal fluid volume. For this purpose, we used in vivo structural T2-weighted magnetic resonance imaging of 89 fetuses (48 controls and 41 cases with iFVM). Our results indicate abnormal development of transient zones/compartments belonging to both hemispheres (i.e. on the side with and also on the contralateral side without a dilated ventricle) in fetuses with iFVM. Specifically, compared to controls, we observed enlargement of proliferative zones and overgrowth of the cortical plate in iFVM with associated reduction of volumes of central structures, subplate, and fetal white matter. These results indicate that enlarged lateral ventricles might be linked to the development of transient fetal zones and that global brain development should be taken into consideration when evaluating iFVM.
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