ArticlePloS one2022
Impact of smoking status and chronic obstructive pulmonary disease on pulmonary complications post lung cancer surgery.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Smoking and Complications After Cancer Surgery: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Timing effects of short-term smoking cessation on lung cancer postoperative complications: a systematic review and meta-analysis.World journal of surgical oncology · 2024Pooled it
- The Effect of Albuterol Spray on Hypoxia and Bronchospasm in Patients with Chronic Obstructive Pulmonary Disease (COPD) under General Anesthesia: A bouble-Blind Randomized Clinical Trial.Ethiopian journal of health sciences · 2023Trial
- Perioperative safety and risk stratification of simultaneous resection for multiple pulmonary nodules via video-assisted thoracoscopic surgery: a retrospective cohort study.Translational lung cancer research · 2026Article
- Tumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancer.The Journal of thoracic and cardiovascular surgery · 2026Article
- The impact of neoadjuvant chemoimmunotherapy on pulmonary function in non-small cell lung cancer patients.Translational lung cancer research · 2026Article
- Construction of risk factors and nomogram model related to thoracoscopic postoperative complications of stage I non-small cell lung cancer.BMC surgery · 2026Article
- Soluble Major Histocompatibility Complex I-Related Chain A (sMICA)*008 Levels Associate with Smoking, Presence of Chronic Obstructive Pulmonary Disease, and Prevalence of Lung Cancer.Journal of clinical medicine · 2026Article
- Tumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancer.bioRxiv : the preprint server for biology · 2026Article
- Construction and validation of a predictive model for postoperative respiratory failure in esophageal cancer patients.Journal of thoracic disease · 2025Article
- Association Between Preoperative COVID-19 Infection and Postoperative Outcomes in Patients with Obstructive Sleep Apnea Undergoing Metabolic Surgery: A Retrospective Analysis.Obesity surgery · 2025Article
- Effect of pulmonary rehabilitation on lung cancer surgery outcomes: a matched-case analysis.Perioperative medicine (London, England) · 2025Article
- Perioperative Challenges: Analysis of Surgical Complications in Screening Lung Carcinoma Patient.Cureus · 2024Article
- Exploring Inflammatory Parameters in Lung Cancer Patients: A Retrospective Analysis.Journal of personalized medicine · 2024Article
- Article
- Optimal period of smoking cessation to reduce the incidence of postoperative pulmonary complications in lung cancer.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Biological and Genetic Mechanisms of COPD, Its Diagnosis, Treatment, and Relationship with Lung Cancer.Biomedicines · 2023Review
- Factors associated with immediate postoperative pulmonary complications after Appendectomies under general anesthesia: A retrospective analysis.Qatar medical journal · 2023Article
- Review
- Establishment of Thoracic Surgical Difficulty Assessment Scale based on Delphi method.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSmoking and chronic obstructive pulmonary disease (COPD) are associated with an increased risk of post-operative pulmonary complications (PPCs) following lung cancer resection. It remains unclear whether smoking cessation reduces this risk.
methodsRetrospective review of a large, prospectively collected database of over 1000 consecutive resections for lung cancer in a quaternary lung cancer centre over a 23-year period.
resultsOne thousand and thirteen patients underwent curative-intent lobectomy or pneumonectomy between 1995 and 2018. Three hundred and sixty-two patients (36%) were ex-smokers, 314 (31%) were current smokers and 111 (11%) were never smokers. A pre-operative diagnosis of COPD was present in 57% of current smokers, 57% of ex-smokers and 20% of never smokers. Just over 25% of patients experienced a PPC. PPCs were more frequent in current smokers compared to never smokers (27% vs 17%, p = 0.036), however, no difference was seen between current and ex-smokers (p = 0.412) or between never and ex-smokers (p = 0.113). Those with a diagnosis of COPD, independent of smoking status, had a higher frequency of both PPCs (65% vs 35%, p<0.01) and overall complications (60% vs 40%, p<0.01) as well as a longer length of hospital stay (10 vs 9 days, p<0.01).
conclusionSmoking and COPD are both associated with a higher rate of PPCs post lung cancer resection. COPD, independent of smoking status, is also associated with an increased overall post-operative complication rate and length of hospital stay. An emphasis on COPD treatment optimisation, rather than smoking cessation in isolation, may help improve post-operative outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.