Evidence map›Paper›PMID 35349370›Full record

ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2022

Epidermal Growth Factor Receptor Inhibition in Epidermal Growth Factor Receptor-Amplified Gastroesophageal Cancer: Retrospective Global Experience.

Steven B Maron, Stephanie Moya, Federica Morano, Matthew J Emmett, Joanne F Chou, Shalom Sabwa, Henry Walch, Bryan Peterson, Alexa B Schrock, Liangliang Zhang and 20 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  12. Article
  13. Perioperative Tailored Treatments for Gastric Cancer: Times Are Changing.International journal of molecular sciences · 2023
    Review
  14. Does immunotherapy change the treatment paradigm in metastatic gastric cancer?Medical oncology (Northwood, London, England) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 16 institutions in 6 countries.

Steven B MaronDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-8794-130X
Stephanie MoyaDepartment of Medicine, Division of Hematology-Oncology, University of Chicago School of Medicine, Chicago, IL.
Federica MoranoOncologia Medica, Instituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID 0000-0002-5306-3596
Matthew J EmmettMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-8855-423X
Joanne F ChouDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Shalom SabwaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Henry WalchDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-1188-350X
Bryan PetersonDepartment of Medicine, Division of Hematology-Oncology, University of Chicago School of Medicine, Chicago, IL.
Alexa B SchrockFoundation Medicine, Inc, Cambridge, MA.ORCID 0000-0003-0106-9096
Liangliang ZhangFoundation Medicine, Inc, Cambridge, MA.
Yelena Y JanjigianDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-5357-5858
Sree ChalasaniDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Geoffrey Y KuDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Umut DiselDepartment of Medical Oncology, Adana Acibadem Hospital, Adana, Turkey.ORCID 0000-0003-0028-5176
Peter EnzingerDepartment of Medical Oncology, Dana-Farber Cancer Institute & Harvard Medical School, Boston, MA.
Nataliya UbohaDepartment of Medicine, Section of Hematology & Oncology, Carbone Cancer Center, University of Wisconsin, Madison, WI.
Shumei KatoDepartment of Medicine, University of California San Diego Moores Cancer Center, La Jolla, CA.ORCID 0000-0003-1193-1815
Takayuki YoshinoDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.ORCID 0000-0002-0489-4756
Kohei ShitaraDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.ORCID 0000-0001-5196-3630
Yoshiaki NakamuraDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.ORCID 0000-0002-5241-6855
Anwaar SaeedDepartment of Medicine, Division of Medical Oncology, Kansas University Cancer Center, Kansas City, KS.ORCID 0000-0001-8024-9401
Pashtoon M KasiDivision of Hematology, Oncology and Blood and Marrow Transplantation, Department of Medicine, University of Iowa, Iowa City, IA.ORCID 0000-0002-5169-7085
Joseph ChaoDepartment of Developmental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA.ORCID 0000-0002-1809-504X
Jeeyun LeeDivision of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID 0000-0002-4911-6165
Marinela CapanuDepartment of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Zev WainbergDivision of Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA.ORCID 0000-0002-7142-1246
Russell PettyDivision of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom.
Filippo PietrantonioOncologia Medica, Instituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID 0000-0002-8530-8420
Samuel J KlempnerMassachusetts General Hospital, Boston, MA.ORCID 0000-0002-4062-0808
Daniel V T CatenacciDepartment of Medicine, Division of Hematology-Oncology, University of Chicago School of Medicine, Chicago, IL.ORCID 0000-0001-7517-8020
Memorial Sloan Kettering Cancer Center · USNational Cancer Center Hospital East · JPUniversity of Chicago · USFondazione IRCCS Istituto Nazionale dei Tumori · ITFoundation Medicine (United States)Massachusetts General Hospital · USAcıbadem Adana Hospital · TRCity of Hope · USHarvard University · USSamsung Medical Center · KRThe University of Kansas Cancer Center · USUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of Dundee · GBUniversity of Iowa · USUniversity of Wisconsin–Madison · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeSubset analyses from phase III evaluation of epidermal growth factor receptor inhibition (EGFRi) suggest improved outcomes in patients with PATIENTS AND

methodsA total of 60 patients from 15 tertiary cancer centers in six countries met the inclusion criteria. These criteria required histologically confirmed GEA in the metastatic or unresectable setting with

resultsSixty patients with

conclusionPatients with

Indexed as

AdenocarcinomaEsophageal NeoplasmsStomach NeoplasmsAntibodies, BispecificErbB ReceptorsHumansIn Situ Hybridization, FluorescenceRetrospective StudiesamivantamabAntibodies, BispecificErbB Receptors

Identifiers

PMID35349370
PMCPMC9467681
OpenAlexW4220783634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.