Evidence map›Paper›PMID 35349300›Full record

ArticleScience signaling2022

Adenosine signaling activates ATP-sensitive K

Maria Sancho, Nicholas R Klug, Amreen Mughal, Masayo Koide, Saul Huerta de la Cruz, Thomas J Heppner, Adrian D Bonev, David Hill-Eubanks, Mark T Nelson

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. KFrontiers in neurology · 2024
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Pericyte KNature cardiovascular research · 2026
    Article
  9. Cantú Syndrome: A Poorly Understood Multi-Organ Disorder.International journal of molecular sciences · 2026
    Review
  10. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Rediscovery of pericytes within the neurovascular unit for cerebral ischemia/reperfusion injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  12. Chemogenetic modulation of CNS pericytes: Impact on pericyte CaMolecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  13. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Maria SanchoDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0003-4750-1040
Nicholas R KlugDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0001-7540-0306
Amreen MughalDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0002-0046-2286
Masayo KoideDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0002-1381-7074
Saul Huerta de la CruzDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0002-5968-9506
Thomas J HeppnerDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0001-8052-7192
Adrian D BonevDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0002-6866-1863
Mark T NelsonDepartment of Pharmacology, University of Vermont, Burlington, VT 05405-0068, USA.ORCID 0000-0002-6608-8784
University of Vermont · US

Funding

Vermont Center for Cardiovascular and Brain HealthP20GM135007 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Todd Adams Clason · 2020 to 2026
$17.4M
Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
Transitional Segment Hypercontractility in Small Vessel Disease with Intracerebral HemorrhageF32HL152576 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KLUG, NICHOLAS RYAN · 2020 to 2022
$201k
NHLBI NIH HHS F32 HL152576NHLBI NIH HHS R35 HL140027NIGMS NIH HHS P20 GM135007NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

The dense network of capillaries composed of capillary endothelial cells (cECs) and pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron- and glial-derived compounds that enhance regional and global cerebral perfusion. The membrane potential (

Indexed as

Endothelial CellsPericytesAdenosineAdenosine TriphosphateAnimalsCapillariesKATP ChannelsMiceAdenosineAdenosine TriphosphateKATP Channels

Identifiers

PMID35349300
PMCPMC9623876
OpenAlexW4220901583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.