Evidence map›Paper›PMID 35349181›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

ClC-K2 Cl

Kyrylo Pyrshev, Naghmeh Hassanzadeh Khayyat, Anna Stavniichuk, Viktor N Tomilin, Oleg Zaika, Nirupama Ramkumar, Oleh Pochynyuk

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Intercalated Cell ClC-K2 Channel Contributes to Systemic ClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.American journal of physiology. Renal physiology · 2024
    Article
  5. ClC-K Kidney Chloride Channels: From Structure to Pathology.Handbook of experimental pharmacology · 2024
    Article
  6. TRPV4 expression in the renal tubule is necessary for maintaining whole body KAmerican journal of physiology. Renal physiology · 2023
    Article
  7. Biomolecules · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kyrylo PyrshevDepartment of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Naghmeh Hassanzadeh KhayyatDepartment of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Anna StavniichukDepartment of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Viktor N TomilinDepartment of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Oleg ZaikaDepartment of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, USA.
Nirupama RamkumarDivision of Nephrology and Hypertension, University of Utah Health, Salt Lake City, Utah, USA.
Oleh PochynyukDepartment of Integrative Biology and Pharmacology, the University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-5397-6897
The University of Texas Health Science Center at Houston · USUniversity of Utah · US

Funding

Physiology of ClC-K2/b Cl- channel in the collecting ductR01DK117865 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2019 to 2023
$1.7M
Regulation of K+ balance by distal nephron TRPV4 channelR01DK119170 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2018 to 2022
$1.7M
Aldosterone-independent regulation of ENaC by systemic saltR01DK095029 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095029NIDDK NIH HHS R01 DK117865NIDDK NIH HHS R01 DK119170
6 · The paper itself

Abstract

The collecting duct is a highly adaptive terminal part of the nephron, which is essential for maintaining systemic homeostasis. Principal and intercalated cells perform different physiological tasks and exhibit distinctive morphology. However, acid-secreting A- and base secreting B-type of intercalated cells cannot be easily separated in functional studies. We used BCECF-sensitive intracellular pH (pH

Indexed as

AcidosisKidney Tubules, CollectingAnimalsAnion Transport ProteinsMiceNephronsSulfate TransportersAnion Transport ProteinsSulfate Transportersacid-base disordersAE1intracellular pHpendrinV-ATPase

Identifiers

PMID35349181
PMCPMC9014849
OpenAlexW4220802527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.