ReviewJournal of endocrinological investigation2022
The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives.
Review in Journal of endocrinological investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Machine Learning Evaluation of Semen Analysis Could Reveal New Infertility-Related Markers: A Pilot Study.The world journal of men's health · 2026Article
- Review
- Exploratory Review on Male Fertility Potential of Acetyl-Eugenol: Mechanistic Insights, Experimental Evidence, and Therapeutic Prospects.Journal of experimental pharmacology · 2026Review
- High prevalence of gonadal dysfunction in pediatric sarcoma survivors: insights from hormonal and clinical markers.Frontiers in pediatrics · 2026Article
- Development of a cAMP biosensor-based assay for measuring serum bioactive concentrations of FSH.PloS one · 2026Article
- Article
- Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.Journal of endocrinological investigation · 2023Review
- Bladder Neck Obstruction: Experience and Management in a Sperm Bank.Life (Basel, Switzerland) · 2023Article
- Comment on Boitrelle et al. The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe current clinical practice in reproductive medicine should pose the couple at the centre of the diagnostic-therapeutic management of infertility and requires intense collaboration between the andrologist, the gynaecologist and the embryologist. The andrologist, in particular, to adequately support the infertile couple, must undertake important biological, psychological, economical and ethical task. Thus, this paper aims to provide a comprehensive overview of the multifaceted role of the andrologist in the study of male factor infertility.
methodsA comprehensive Medline, Embase and Cochrane search was performed including publications between 1969 and 2021.
resultsAvailable evidence indicates that a careful medical history and physical examination, followed by semen analysis, always represent the basic starting points of the diagnostic work up in male partner of an infertile couple. Regarding treatment, gonadotropins are an effective treatment in case of hypogonadotropic hypogonadism and FSH may be used in men with idiopathic infertility, while evidence supporting other hormonal and nonhormonal treatments is either limited or conflicting. In the future, pharmacogenomics of FSHR and FSHB as well as innovative compounds may be considered to develop new therapeutic strategies in the management of infertility.
conclusionTo provide a high-level of care, the andrologist must face several critical diagnostical and therapeutical steps. Even though ART may be the final and decisive stage of this decisional network, neglecting to treat the male partner may ultimately increase the risks of negative outcome, as well as costs and psychological burden for the couple itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.