Evidence map›Paper›PMID 35349099›Full record

ArticleHead and neck pathology2022

Expression of a Tumor Stem Cell Marker (Aldehyde Dehydrogenase 1-ALDH1) in Benign Epithelial Odontogenic Lesions.

Gustavo Alcântara da Trindade, Leorik Pereira da Silva, Pedro Paulo de Andrade Santos, Leão Pereira Pinto, Lélia Batista de Souza

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Gustavo Alcântara da TrindadeFederal University of Rio Grande do Norte, Natal, RN, Brazil.
Leorik Pereira da SilvaFederal University of Campina Grande, Patos, PB, Brazil.ORCID http://orcid.org/0000-0003-1890-8415
Pedro Paulo de Andrade SantosDepartment of Morphology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.ORCID http://orcid.org/0000-0002-5793-3886
Leão Pereira PintoDepartment of Oral Pathology, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil.ORCID http://orcid.org/0000-0001-8563-6945
Lélia Batista de SouzaDepartment of Oral Pathology, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, CEP 59056-000, Brazil. leliabsouza@gmail.com.ORCID http://orcid.org/0000-0002-1130-3870
Universidade Federal do Rio Grande do Norte · BRUniversidade Federal de Campina Grande · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico L.B.S is a Research Productivity Fellow at CNPq.
6 · The paper itself

Abstract

The morphological diversity and different biological behaviors of human lesions has been attributed to the presence of cells with stem cell (SC) characteristics. Among SC markers, ALDH1 has been used in studies investigating different neoplasms and high expression of this marker was associated with clinicopathological features and prognosis in some groups. The aim of this study was to analyze the presence and distribution of SCs based on the expression of ALDH1 in epithelial odontogenic cysts and tumors. The sample consisted of 80 cases (20 dentigerous cysts (DCs), 20 odontogenic keratocysts (OKCs), 20 ameloblastomas (AMs), and 20 adenomatoid odontogenic tumors (AOTs). An immunoreactivity score was obtained from the percentage of positive cells and intensity of immunostaining. A level of 5% (p < 0.05) was adopted for the statistical tests. Immunoexpression of ALDH1 was observed in cytoplasm and nucleus-cytoplasm. The median scores indicated significantly higher expression in OKCs and DCs compared to AMs (p < 0.0001) and AOTs (p < 0.0001). In the tumor stroma and cystic capsule, immunoreactivity was detected in all odontogenic cysts studied and in 85% and 90% of AMs and AOTs, respectively. The expression of ALDH1 suggests the presence of SCs in the odontogenic lesions studied. Epithelial immunoexpression was higher in odontogenic cysts than in odontogenic tumors.

Indexed as

AmeloblastomaOdontogenic CystsOdontogenic TumorsAldehyde Dehydrogenase 1 FamilyHumansImmunohistochemistryNeoplastic Stem CellsAldehyde Dehydrogenase 1 FamilyAldehyde dehydrogenase 1 familyBiomarkersImmunohistochemistryOdontogenic cystsOdontogenic tumorsStem cells

Identifiers

PMID35349099
PMCPMC9424418
OpenAlexW4220922185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.